Genetics and Molecular Biology (Jan 2009)

Increased risk of venous thrombosis by AB alleles of the ABO blood group and Factor V Leiden in a Brazilian population

  • Magaly B.P.L.V. Lima,
  • Aldemir Branco de Oliveira-Filho,
  • Júlia F. Campos,
  • Fárida C.B.C. Melo,
  • Washington Batista das Neves,
  • Raul Antônio Morais Melo,
  • José Alexandre Rodrigues Lemos

DOI
https://doi.org/10.1590/S1415-47572009000200010
Journal volume & issue
Vol. 32, no. 2
pp. 264 – 267

Abstract

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Most cases of a predisposition to venous thrombosis are caused by resistance to activated protein C, associated in 95% of cases with the Factor V Leiden allele (FVL or R506Q). Several recent studies report a further increased risk of thrombosis by an association between the AB alleles of the ABO blood group and Factor V Leiden. The present study investigated this association with deep vein thrombosis (DVT) in individuals treated at the Hemocentro de Pernambuco in northeastern Brazil. A case-control comparison showed a significant risk of thrombosis in the presence of Factor V Leiden (OR = 10.1), which was approximately doubled when the AB alleles of the ABO blood group were present as well (OR = 22.3). These results confirm that the increased risk of deep vein thrombosis in the combined presence of AB alleles and Factor V Leiden is also applicable to the Brazilian population suggesting that ABO blood group typing should be routinely added to FVL in studies involving thrombosis.

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