Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan

Alireza Noormohammadi; Amirabbas Khodakarami; Ricardo Gutierrez-Garcia; Hyun Ju Lee; Seda Koyuncu; Tim König; Christina Schindler; Isabel Saez; Azra Fatima; Christoph Dieterich; David Vilchez

doi:10.1038/ncomms13649

Nature Communications (Nov 2016)

Somatic increase of CCT8 mimics proteostasis of human pluripotent stem cells and extends C. elegans lifespan

Alireza Noormohammadi,
Amirabbas Khodakarami,
Ricardo Gutierrez-Garcia,
Hyun Ju Lee,
Seda Koyuncu,
Tim König,
Christina Schindler,
Isabel Saez,
Azra Fatima,
Christoph Dieterich,
David Vilchez

Affiliations

Alireza Noormohammadi: Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
Amirabbas Khodakarami: Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
Ricardo Gutierrez-Garcia: Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
Hyun Ju Lee: Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
Seda Koyuncu: Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
Tim König: Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
Christina Schindler: Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
Isabel Saez: Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
Azra Fatima: Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne
Christoph Dieterich: Department of Internal Medicine III and Klaus Tschira Institute for Computational Cardiology, Section of Bioinformatics and Systems Cardiology
David Vilchez: Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne

DOI: https://doi.org/10.1038/ncomms13649
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

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Pluripotent stem cells are thought to require a highly active proteostatic machinery. Here, the authors show that CCT8, a subunit of the proteostatic chaperonin complex, is increased in pluripotent stem cells, and that overexpression of CCT8 in worms increases cellular proteostasis and organismal longevity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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