The influence of biologically active agents on the reaction sympathetic adrenal system and dynamics of activity of different isoforms of no-synthase in pregnant wistar rats of hypoxia

Abstract

The influence of dietary supplements namivit and superprotamin on the reaction sympathetic adrenal system, as well as on the activity of different isoforms of NOS in pregnant Wistar rats under the influence of acute hypobaric hypoxia. It was revealed that namivit significantly reduced the severity of stress-response reaction of the organism to hypoxia, whereas superprotamin caused no significant decrease significantly the content of catecholamines in the blood. It is shown that the introduction of rats studied drugs restored decreased from the onset of hypoxic stress activity of Ca2+-dependent NO-synthase and suppressed the induction of iNOS, thus increasing the body's resistance to the effects of hypoxia. This antihy effect namivit was expressed to a greater extent than superprotamin.

Keywords

• hypoxia
• pregnancy
• catecholamines
• ca2+-dependent no-synthase
• biologically active agents