Functional in vivo characterization of sox10 enhancers in neural crest and melanoma development

Abstract

By performing ATAC-Seq on zebrafish melanoma tumours, Cunningham et al identify putative sox10 enhancers with embryonic activity in zebrafish. They identify a region upstream of sox10, termed peak5, that is needed for full expression of embryonic sox10 and for adult stripe patterning demonstrating an enhancer function for peak5 and provide insights into neural crest development and melanoma initiation.