Nature Communications (Oct 2020)

Autophagy facilitates adaptation of budding yeast to respiratory growth by recycling serine for one-carbon metabolism

  • Alexander I. May,
  • Mark Prescott,
  • Yoshinori Ohsumi

DOI
https://doi.org/10.1038/s41467-020-18805-x
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 14

Abstract

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Autophagy is important during stress and development, but how the metabolites generated are used by the cell remains unclear. Here, the authors demonstrate that budding yeast require autophagy to provide serine for one-carbon metabolism during the switch from glycolytic to respiratory growth.