Effect of resistance exercise on vasculardiastolic function and atherosclerosis in patients with hypertension

Abstract

Objective To investigate the effect of resistance exercise on self-management ability, vascular diastolic function and atherosclerosis in patients with hypertension. Methods A total of 160 patients with hypertension treated in Sinopharm Dongfeng General Hospital from December 2019 to January 2022 were enrolled in this study. Patients were divided into study group (n=80) and traditional group (n=80) by random number table method. The traditional group was given routine aerobic exercise training based on drug therapy, and the research group was given resistance exercise training based on traditional therapy. Patients in both groups received intervention for 3 months, and the changes of vascular endothelial diastolic function and atherosclerosis were compared and analyzed before and after training. Results After training , the systolic blood pressure and diastolic blood pressure of the two groups decreased significantly compared with those before training (P＜0.05), and the study group was significantly lower than the traditional group (P＜0.05). The scores of self-management ability (45.28±3.17, 40.10±2.22) in the study group and traditional group were significantly higher than those before training (31.48±3.18, 31.54±2.58); The score of self-management ability in study group was significantly lower than that in traditional group (t=141.972, P＜0.05). The serum levels of lipoprotein-associated phospholipase 2 (Lp-PLA2) and homocysteine (Hcy) in two groups decreased significantly compared with those before training (P＜0.05)，and the levels of serum Lp-PLA2 and Hcy in the study group were significantly higher than those in the traditional group (P＜0.05). The change rate of artery diameter and the change rate of artery diameter of endothelium-dependent vasodilation function in the two groups were significantly higher than those before training, and the study group was significantly higher than the traditional group (P＜0.05). There was no significant difference in carotid intima-media thickness between the two groups after training and before training, and there was no significant difference between the study group and the traditional group (P＞0.05). Conclusion Resistance exercise can improve vascular endothelial relaxation function and atherosclerosis status, inhibit the expression of Lp-PLA2 and Hcy, reduce blood pressure continuously, and improve the self-management ability of patients with hypertension.

Keywords

• resistance exercise
• hypertension
• vascular diastolic function
• atherosclerosis
• lipoprotein-associated phospholipase 2
• homocysteine