Nature Communications (Jan 2018)
Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles
- Eduardo Reátegui,
- Kristan E. van der Vos,
- Charles P. Lai,
- Mahnaz Zeinali,
- Nadia A. Atai,
- Berent Aldikacti,
- Frederick P. Floyd,
- Aimal H. Khankhel,
- Vishal Thapar,
- Fred H. Hochberg,
- Lecia V. Sequist,
- Brian V. Nahed,
- Bob S. Carter,
- Mehmet Toner,
- Leonora Balaj,
- David T. Ting,
- Xandra O. Breakefield,
- Shannon L. Stott
Affiliations
- Eduardo Reátegui
- Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School
- Kristan E. van der Vos
- Neurodiscovery Center, Massachusetts General Hospital, Harvard Medical School
- Charles P. Lai
- Neurodiscovery Center, Massachusetts General Hospital, Harvard Medical School
- Mahnaz Zeinali
- Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School
- Nadia A. Atai
- Neurodiscovery Center, Massachusetts General Hospital, Harvard Medical School
- Berent Aldikacti
- Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School
- Frederick P. Floyd
- Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School
- Aimal H. Khankhel
- Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School
- Vishal Thapar
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Fred H. Hochberg
- Department of Neurosurgery, University of California San Diego
- Lecia V. Sequist
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Brian V. Nahed
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Bob S. Carter
- Department of Neurosurgery, University of California San Diego
- Mehmet Toner
- Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School
- Leonora Balaj
- Neurodiscovery Center, Massachusetts General Hospital, Harvard Medical School
- David T. Ting
- Massachusetts General Hospital Cancer Center, Harvard Medical School
- Xandra O. Breakefield
- Neurodiscovery Center, Massachusetts General Hospital, Harvard Medical School
- Shannon L. Stott
- Center for Engineering in Medicine, Massachusetts General Hospital, Harvard Medical School
- DOI
- https://doi.org/10.1038/s41467-017-02261-1
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Extracellular vesicles can carry many different types of biological cargo and have been investigated as a biomarker for cancer diagnosis. Here the authors develop a microfluidic platform for rapid and sensitive isolation of tumor-specific extracellular vesicles.
