Does cellular senescence play an important role in the prognosis of sarcomatoid carcinoma of the pancreas?

Abstract

Abstract Aim Sarcomatoid carcinoma of the pancreas (SCP) is an extremely rare and aggressive disease with poor prognosis. We have already reported a rare case of SCP with long-term survival. In the present article, we investigate the underlying mechanisms of patient’s long-term survival from the point of view of cellular senescence which was examined in three SCP cases, including our reported case, using immunohistochemical analysis. Findings The expressions of cellular senescence marker were observed in the sarcomatous component of the patient with long-term survival but not observed in the other patients with short- term survival. Thus, we can speculate that cellular senescence might play an important role in the reduction of the cell proliferative and metastatic activities of sarcomatous cells, leading to long-term patient survival.

Keywords

• Sarcomatoid carcinoma of the pancreas
• Long-term survival
• Epithelial-mesenchymal transition
• cellular senescence
• TGF-β