E-Journal of Chemistry (Jan 2011)

Synthesis and In Vitro Antibacterial Activity of New 2-(1-Methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles

  • Bahram Letafat,
  • Negar Mohammadhosseini,
  • Ali Asadipour,
  • Alireza Foroumadi

DOI
https://doi.org/10.1155/2011/642071
Journal volume & issue
Vol. 8, no. 3
pp. 1120 – 1123

Abstract

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In the present study we report the synthesis and antibacterial activity of a new series 2-(1-methyl-4-nitro-1H-imidazol-5-ylsulfonyl)-1,3,4-thiadiazoles (6a-c). Compounds 6a-c were tested in vitro by the conventional agar dilution method against a panel of microorganisms including gram-negative and gram-positive bacteria. Compound 6b with 5-(5-nitrofuran-2-yl)-residue on 1,3,4-thiadiazole scaffold have shown promising antibacterial activities against gram-positive bacteria including Staphylococcus aureus, Staphylococcus epidermidis and Bacillus subtilis.