Communications Biology (Mar 2023)
Isoform-specific knockdown of long and intermediate prolactin receptors interferes with evolution of B-cell neoplasms
- Adeleh Taghi Khani,
- Anil Kumar,
- Ashly Sanchez Ortiz,
- Kelly C. Radecki,
- Soraya Aramburo,
- Sung June Lee,
- Zunsong Hu,
- Behzad Damirchi,
- Mary Y. Lorenson,
- Xiwei Wu,
- Zhaohui Gu,
- William Stohl,
- Ignacio Sanz,
- Eric Meffre,
- Markus Müschen,
- Stephen J. Forman,
- Jean L. Koff,
- Ameae M. Walker,
- Srividya Swaminathan
Affiliations
- Adeleh Taghi Khani
- Department of Systems Biology, Beckman Research Institute of City of Hope
- Anil Kumar
- Department of Systems Biology, Beckman Research Institute of City of Hope
- Ashly Sanchez Ortiz
- Department of Systems Biology, Beckman Research Institute of City of Hope
- Kelly C. Radecki
- Division of Biomedical Sciences, School of Medicine, University of California, Riverside
- Soraya Aramburo
- Department of Systems Biology, Beckman Research Institute of City of Hope
- Sung June Lee
- Department of Systems Biology, Beckman Research Institute of City of Hope
- Zunsong Hu
- Department of Systems Biology, Beckman Research Institute of City of Hope
- Behzad Damirchi
- Department of Systems Biology, Beckman Research Institute of City of Hope
- Mary Y. Lorenson
- Division of Biomedical Sciences, School of Medicine, University of California, Riverside
- Xiwei Wu
- Department of Molecular and Cellular Biology, City of Hope National Medical Center
- Zhaohui Gu
- Department of Systems Biology, Beckman Research Institute of City of Hope
- William Stohl
- Division of Rheumatology, Department of Medicine, Keck School of Medicine of the University of Southern California
- Ignacio Sanz
- Department of Medicine, Division of Rheumatology, Lowance Center for Human Immunology, Emory University
- Eric Meffre
- Division of Immunology and Rheumatology, Stanford University School of Medicine
- Markus Müschen
- Center of Molecular and Cellular Oncology, Yale School of Medicine
- Stephen J. Forman
- Department of Hematology & Hematopoietic Cell Transplantation, City of Hope National Medical Center
- Jean L. Koff
- Department of Hematology and Medical Oncology, Emory University School of Medicine
- Ameae M. Walker
- Division of Biomedical Sciences, School of Medicine, University of California, Riverside
- Srividya Swaminathan
- Department of Systems Biology, Beckman Research Institute of City of Hope
- DOI
- https://doi.org/10.1038/s42003-023-04667-8
- Journal volume & issue
-
Vol. 6,
no. 1
pp. 1 – 15
Abstract
Malignant human B cells express autocrine prolactin (PRL), which has the potential to engage the long isoform and intermediate form of the PRL receptor to promote proliferation and/or survival.
