Nature Communications (Jul 2022)
Periosteal stem cells control growth plate stem cells during postnatal skeletal growth
- Masayuki Tsukasaki,
- Noriko Komatsu,
- Takako Negishi-Koga,
- Nam Cong-Nhat Huynh,
- Ryunosuke Muro,
- Yutaro Ando,
- Yuka Seki,
- Asuka Terashima,
- Warunee Pluemsakunthai,
- Takeshi Nitta,
- Takashi Nakamura,
- Tomoki Nakashima,
- Shinsuke Ohba,
- Haruhiko Akiyama,
- Kazuo Okamoto,
- Roland Baron,
- Hiroshi Takayanagi
Affiliations
- Masayuki Tsukasaki
- Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
- Noriko Komatsu
- Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
- Takako Negishi-Koga
- Department of Community Medicine and Research for Bone and Joint Diseases, Juntendo University Graduate School of Medicine
- Nam Cong-Nhat Huynh
- Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
- Ryunosuke Muro
- Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
- Yutaro Ando
- Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
- Yuka Seki
- Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
- Asuka Terashima
- Department of Osteoimmunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
- Warunee Pluemsakunthai
- Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
- Takeshi Nitta
- Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
- Takashi Nakamura
- Department of Biochemistry, Tokyo Dental College
- Tomoki Nakashima
- Department of Cell Signaling, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University
- Shinsuke Ohba
- Department of Cell Biology, Institute of Biomedical Sciences, Nagasaki University
- Haruhiko Akiyama
- Department of Orthopaedic Surgery, School of Medicine, Gifu University
- Kazuo Okamoto
- Department of Osteoimmunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
- Roland Baron
- Division of Bone and Mineral Research, Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine
- Hiroshi Takayanagi
- Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
- DOI
- https://doi.org/10.1038/s41467-022-31592-x
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 11
Abstract
Intramembranous and endochondral bone formation have been considered to be independent processes mediated by independent stem cells. Here the authors show that periosteal stem cells participate in both types of bone formation, supporting endochondral formation by producing Ihh.
