Nature Communications (Jul 2021)
Whole-genome profiling of nasopharyngeal carcinoma reveals viral-host co-operation in inflammatory NF-κB activation and immune escape
- Jeff P. Bruce,
- Ka-Fai To,
- Vivian W. Y. Lui,
- Grace T. Y. Chung,
- Yuk-Yu Chan,
- Chi Man Tsang,
- Kevin Y. Yip,
- Brigette B. Y. Ma,
- John K. S. Woo,
- Edwin P. Hui,
- Michael K. F. Mak,
- Sau-Dan Lee,
- Chit Chow,
- Sharmila Velapasamy,
- Yvonne Y. Y. Or,
- Pui Kei Siu,
- Samah El Ghamrasni,
- Stephenie Prokopec,
- Man Wu,
- Johnny S. H. Kwan,
- Yuchen Liu,
- Jason Y. K. Chan,
- C. Andrew van Hasselt,
- Lawrence S. Young,
- Christopher W. Dawson,
- Ian C. Paterson,
- Lee-Fah Yap,
- Sai-Wah Tsao,
- Fei-Fei Liu,
- Anthony T. C. Chan,
- Trevor J. Pugh,
- Kwok-Wai Lo
Affiliations
- Jeff P. Bruce
- Princess Margaret Cancer Centre, University Health Network
- Ka-Fai To
- Department of Anatomical and cellular Pathology, The Chinese University of Hong Kong
- Vivian W. Y. Lui
- School of Biomedical Sciences, The Chinese University of Hong Kong
- Grace T. Y. Chung
- Department of Anatomical and cellular Pathology, The Chinese University of Hong Kong
- Yuk-Yu Chan
- Department of Anatomical and cellular Pathology, The Chinese University of Hong Kong
- Chi Man Tsang
- Department of Anatomical and cellular Pathology, The Chinese University of Hong Kong
- Kevin Y. Yip
- Department of Computer Science and Engineering, The Chinese University of Hong Kong
- Brigette B. Y. Ma
- State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong
- John K. S. Woo
- Department of Otorhinolaryngology, Head and Neck Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong
- Edwin P. Hui
- State Key Laboratory of Translational Oncology, The Chinese University of Hong Kong
- Michael K. F. Mak
- Department of Anatomical and cellular Pathology, The Chinese University of Hong Kong
- Sau-Dan Lee
- Department of Computer Science and Engineering, The Chinese University of Hong Kong
- Chit Chow
- Department of Anatomical and cellular Pathology, The Chinese University of Hong Kong
- Sharmila Velapasamy
- Department of Anatomical and cellular Pathology, The Chinese University of Hong Kong
- Yvonne Y. Y. Or
- Department of Anatomical and cellular Pathology, The Chinese University of Hong Kong
- Pui Kei Siu
- Department of Anatomical and cellular Pathology, The Chinese University of Hong Kong
- Samah El Ghamrasni
- Princess Margaret Cancer Centre, University Health Network
- Stephenie Prokopec
- Princess Margaret Cancer Centre, University Health Network
- Man Wu
- Department of Anatomical and cellular Pathology, The Chinese University of Hong Kong
- Johnny S. H. Kwan
- Department of Anatomical and cellular Pathology, The Chinese University of Hong Kong
- Yuchen Liu
- School of Biomedical Sciences, The Chinese University of Hong Kong
- Jason Y. K. Chan
- Department of Otorhinolaryngology, Head and Neck Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong
- C. Andrew van Hasselt
- Department of Otorhinolaryngology, Head and Neck Surgery, Prince of Wales Hospital, The Chinese University of Hong Kong
- Lawrence S. Young
- Warwick Medical School, University of Warwick
- Christopher W. Dawson
- Warwick Medical School, University of Warwick
- Ian C. Paterson
- Department of Oral & Craniofacial Sciences and Oral Cancer Research and Coordinating Centre, University of Malaya
- Lee-Fah Yap
- Department of Oral & Craniofacial Sciences and Oral Cancer Research and Coordinating Centre, University of Malaya
- Sai-Wah Tsao
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Fei-Fei Liu
- Princess Margaret Cancer Centre, University Health Network
- Anthony T. C. Chan
- Department of Computer Science and Engineering, The Chinese University of Hong Kong
- Trevor J. Pugh
- Princess Margaret Cancer Centre, University Health Network
- Kwok-Wai Lo
- Department of Anatomical and cellular Pathology, The Chinese University of Hong Kong
- DOI
- https://doi.org/10.1038/s41467-021-24348-6
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 15
Abstract
The genomic characterisation of nasopharyngeal carcinoma (NPC) remains crucial. Here, the authors perform whole-genome sequencing for 70 NPCs with EBV gene expression, report the somatic alterations and EBV-mediated effects converging on NF-κB activation and immune escape and identify targetable homozygous MTAP deletions.
