Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A

Régis Joulia; Idaira María Guerrero-Fonseca; Tamara Girbl; Jonathon A. Coates; Monja Stein; Laura Vázquez-Martínez; Eleanor Lynam; James Whiteford; Michael Schnoor; David Voehringer; Axel Roers; Sussan Nourshargh; Mathieu-Benoit Voisin

doi:10.1038/s41467-022-34695-7

Nature Communications (Nov 2022)

Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A

Régis Joulia,
Idaira María Guerrero-Fonseca,
Tamara Girbl,
Jonathon A. Coates,
Monja Stein,
Laura Vázquez-Martínez,
Eleanor Lynam,
James Whiteford,
Michael Schnoor,
David Voehringer,
Axel Roers,
Sussan Nourshargh,
Mathieu-Benoit Voisin

Affiliations

Régis Joulia: William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square
Idaira María Guerrero-Fonseca: William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square
Tamara Girbl: William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square
Jonathon A. Coates: William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square
Monja Stein: William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square
Laura Vázquez-Martínez: William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square
Eleanor Lynam: William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square
James Whiteford: William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square
Michael Schnoor: Department of Molecular Biomedicine, CINVESTAV-IPN
David Voehringer: Department of Infection Biology, University Hospital Erlangen and Friedrich-Alexander University Erlangen-Nuremberg (FAU)
Axel Roers: Institute for Immunology, Heidelberg University Hospital
Sussan Nourshargh: William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square
Mathieu-Benoit Voisin: William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square

DOI: https://doi.org/10.1038/s41467-022-34695-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

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The blood vessel wall is a complex multi-layered structure, yet upon injury or infection, neutrophil leukocytes are rapidly migrating from the blood stream to the affected tissues, by a process termed diapedesis. Authors here show that the final steps of diapedesis through the outer pericyte layer is regulated by perivascular mast cells via IL-17A production.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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