Localization and regional distribution of p23/TMP21 in the brain

Kulandaivelu S. Vetrivel; Anitha Kodam; Ping Gong; Ying Chen; Angèle T. Parent; Satyabrata Kar; Gopal Thinakaran

Neurobiology of Disease (Oct 2008)

Localization and regional distribution of p23/TMP21 in the brain

Kulandaivelu S. Vetrivel,
Anitha Kodam,
Ping Gong,
Ying Chen,
Angèle T. Parent,
Satyabrata Kar,
Gopal Thinakaran

Affiliations

Kulandaivelu S. Vetrivel: Department of Neurobiology, The University of Chicago, Knapp R212, 924 E. 57th Street, Chicago, IL 60637, USA; Department of Neurology, The University of Chicago, Knapp R212, 924 E. 57th Street, Chicago, IL 60637, USA; Department of Pathology, The University of Chicago, Knapp R212, 924 E. 57th Street, Chicago, IL 60637, USA
Anitha Kodam: Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada T6G 2M8; Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta, Canada T6G 2M8; Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada T6G 2M8; Corresponding author. Department of Neurobiology, The University of Chicago, Knapp R212, 924 E. 57th Street, Chicago, IL 60637, USA. Fax: +1 773 834 3808.
Ping Gong: Department of Neurobiology, The University of Chicago, Knapp R212, 924 E. 57th Street, Chicago, IL 60637, USA; Department of Neurology, The University of Chicago, Knapp R212, 924 E. 57th Street, Chicago, IL 60637, USA; Department of Pathology, The University of Chicago, Knapp R212, 924 E. 57th Street, Chicago, IL 60637, USA
Ying Chen: Department of Neurobiology, The University of Chicago, Knapp R212, 924 E. 57th Street, Chicago, IL 60637, USA; Department of Neurology, The University of Chicago, Knapp R212, 924 E. 57th Street, Chicago, IL 60637, USA; Department of Pathology, The University of Chicago, Knapp R212, 924 E. 57th Street, Chicago, IL 60637, USA
Angèle T. Parent: Department of Neurobiology, The University of Chicago, Knapp R212, 924 E. 57th Street, Chicago, IL 60637, USA; Department of Neurology, The University of Chicago, Knapp R212, 924 E. 57th Street, Chicago, IL 60637, USA; Department of Pathology, The University of Chicago, Knapp R212, 924 E. 57th Street, Chicago, IL 60637, USA
Satyabrata Kar: Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Alberta, Canada T6G 2M8; Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta, Canada T6G 2M8; Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada T6G 2M8
Gopal Thinakaran: Department of Neurobiology, The University of Chicago, Knapp R212, 924 E. 57th Street, Chicago, IL 60637, USA; Department of Neurology, The University of Chicago, Knapp R212, 924 E. 57th Street, Chicago, IL 60637, USA; Department of Pathology, The University of Chicago, Knapp R212, 924 E. 57th Street, Chicago, IL 60637, USA; Corresponding author. Department of Neurobiology, The University of Chicago, Knapp R212, 924 E. 57th Street, Chicago, IL 60637, USA. Fax: +1 773 834 3808.

Journal volume & issue: Vol. 32, no. 1
pp. 37 – 49

Abstract

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Sequential processing of amyloid precursor protein by β- and γ-secretases generates Alzheimer's disease (AD)-associated β-amyloid peptides. Recently it was reported that the transmembrane protein p23/TMP21 associates with γ-secretase, and negatively regulates β-amyloid production. Despite the link between p23 function and AD pathogenesis, the expression of p23 has not been examined in the brain. Here, we describe the detailed immunohistochemical characterization of p23 expression in rodent and human brain. We report that p23 is co-expressed with γ-secretase subunits in select neuronal cell populations in rodent brain. Interestingly, the steady-state level of p23 in the brain is high during embryonic development and then declines after birth. Furthermore, the steady-state p23 levels are reduced in the brains of individuals with AD. We conclude that p23 is expressed in neurons throughout the brain and the decline in p23 expression during postnatal development may significantly contribute to enhanced β-amyloid production in the adult brain.

Published in Neurobiology of Disease

ISSN: 0969-9961 (Print); 1095-953X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neurobiology-of-disease

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