Nature Communications (Sep 2018)

Topographic precision in sensory and motor corticostriatal projections varies across cell type and cortical area

  • Bryan M. Hooks,
  • Andrew E. Papale,
  • Ronald F. Paletzki,
  • Muhammad W. Feroze,
  • Brian S. Eastwood,
  • Jonathan J. Couey,
  • Johan Winnubst,
  • Jayaram Chandrashekar,
  • Charles R. Gerfen

DOI
https://doi.org/10.1038/s41467-018-05780-7
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 16

Abstract

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How corticostriatal connections of different pyramidal cell types are organized, particularly in convergent circuits, has not been evaluated in detail. Here, cell type-specific Cre-driver mice reveal that pyramidal tract-type corticostriatal projections, though broadly similar to intratelencephalic-type projections from the same cortical region, are generally more restricted and variable in their topographic termination patterns.