Frontiers in Neurology (Apr 2021)
Analysis of 12 GWAS-Linked Loci With Parkinson’s Disease in the Chinese Han Population
- Liyuan Fan,
- Liyuan Fan,
- Liyuan Fan,
- Changhe Shi,
- Changhe Shi,
- Changhe Shi,
- Xinchao Hu,
- Xinchao Hu,
- Xinchao Hu,
- Zhongxian Zhang,
- Zhongxian Zhang,
- Huimin Zheng,
- Huimin Zheng,
- Huimin Zheng,
- Haiyang Luo,
- Haiyang Luo,
- Haiyang Luo,
- Yu Fan,
- Yu Fan,
- Yu Fan,
- Shuo Zhang,
- Shuo Zhang,
- Shuo Zhang,
- Zhengwei Hu,
- Zhengwei Hu,
- Jing Yang,
- Jing Yang,
- Chengyuan Mao,
- Chengyuan Mao,
- Chengyuan Mao,
- Chengyuan Mao,
- Yuming Xu,
- Yuming Xu,
- Yuming Xu
Affiliations
- Liyuan Fan
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Liyuan Fan
- The Academy of Medical Sciences of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Liyuan Fan
- Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Changhe Shi
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Changhe Shi
- Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Changhe Shi
- Institute of Neuroscience, Zhengzhou University, Zhengzhou, China
- Xinchao Hu
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Xinchao Hu
- The Academy of Medical Sciences of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Xinchao Hu
- Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Zhongxian Zhang
- The Academy of Medical Sciences of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Zhongxian Zhang
- Sino-British Research Centre for Molecular Oncology, National Centre for International Research in Cell and Gene Therapy, School of Basic Medical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China
- Huimin Zheng
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Huimin Zheng
- The Academy of Medical Sciences of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Huimin Zheng
- Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Haiyang Luo
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Haiyang Luo
- The Academy of Medical Sciences of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Haiyang Luo
- Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Yu Fan
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Yu Fan
- The Academy of Medical Sciences of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Yu Fan
- Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Shuo Zhang
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Shuo Zhang
- The Academy of Medical Sciences of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Shuo Zhang
- Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Zhengwei Hu
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Zhengwei Hu
- The Academy of Medical Sciences of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Jing Yang
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Jing Yang
- Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Chengyuan Mao
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Chengyuan Mao
- The Academy of Medical Sciences of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Chengyuan Mao
- Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Chengyuan Mao
- Sino-British Research Centre for Molecular Oncology, National Centre for International Research in Cell and Gene Therapy, School of Basic Medical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou, China
- Yuming Xu
- Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Yuming Xu
- Henan Key Laboratory of Cerebrovascular Diseases, The First Affiliated Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, China
- Yuming Xu
- Institute of Neuroscience, Zhengzhou University, Zhengzhou, China
- DOI
- https://doi.org/10.3389/fneur.2021.623913
- Journal volume & issue
-
Vol. 12
Abstract
A recent large-scale European-originated genome-wide association study identified 38 novel independent risk signals in 37 loci for Parkinson's disease (PD). However, whether these new loci are associated with PD in Asian populations remains elusive. The present study aimed to explore the relationship between the 12 most relevant loci with larger absolute values for these new risk loci and PD in the Chinese Han population. We performed a case-control study including 527 PD patients and 435 healthy controls. In the allele model, it was found that rs10748818/GBF1 was associated with PD in the Chinese Han population [p = 0.035, odds ratio (OR) 1.221, 95% confidence interval (CI) 1.014–1.472
Keywords
