Proteoform Analysis of the Human Olfactory System: A Window into Neurodegenerative Diseases
Eqrem Rusi,
Fiorenza Pennacchia,
Wael Abu Ruqa,
Giuseppina Talarico,
Giuseppe Bruno,
Antonio Minni,
Christian Barbato
Affiliations
Eqrem Rusi
Department of Human Neuroscience, Sapienza University of Rome, 00185 Rome, Italy
Fiorenza Pennacchia
Department of Sense Organs DOS, Sapienza University of Rome, Viale del Policlinico 155, 00161 Roma, Italy
Wael Abu Ruqa
Division of Otolaryngology-Head and Neck Surgery, Ospedale San Camillo de Lellis, ASL-Rieti-Sapienza University, Viale Kennedy, 02100 Rieti, Italy
Giuseppina Talarico
Department of Human Neuroscience, Sapienza University of Rome, 00185 Rome, Italy
Giuseppe Bruno
Department of Human Neuroscience, Sapienza University of Rome, 00185 Rome, Italy
Antonio Minni
Department of Sense Organs DOS, Sapienza University of Rome, Viale del Policlinico 155, 00161 Roma, Italy
Christian Barbato
Institute of Biochemistry and Cell Biology (IBBC), National Research Council (CNR), Sapienza University of Rome, Viale del Policlinico 155, 00161 Roma, Italy
Background: Very little is known about the proteome of the human olfactory system and how diseases associated with olfactory dysfunctions can affect it. With this review, we try to summarize the existing literature on the use of this technique for a better understanding of the neurodegenerative disease process. Methods: We used the PubMed database and found different articles which were then selected independently by three authors. Results: We found 157 articles, of which, after careful selection, only 30 were analyzed in this review. We presented all the associations identified between the protein/pathway alterations neurodegenerative diseases and SARS-CoV-2 infection. Conclusions: We think that the proteome of the olfactory system through blood, saliva, and mucus analysis could be a new way to better understand, diagnose, and finally treat neurodegenerative diseases.
