SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis

Li-Yu Huang; Junjie Zhao; Hao Chen; Lixin Wan; Hiroyuki Inuzuka; Jianping Guo; Xuhong Fu; Yangyang Zhai; Zhaoning Lu; Xuefei Wang; Ze-Guang Han; Yihong Sun; Wenyi Wei

doi:10.1038/s41467-018-06038-y

Nature Communications (Sep 2018)

SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis

Li-Yu Huang,
Junjie Zhao,
Hao Chen,
Lixin Wan,
Hiroyuki Inuzuka,
Jianping Guo,
Xuhong Fu,
Yangyang Zhai,
Zhaoning Lu,
Xuefei Wang,
Ze-Guang Han,
Yihong Sun,
Wenyi Wei

Affiliations

Li-Yu Huang: Key Laboratory of Systems Biomedicine (Ministry of Education) and Collaborative Innovation Center of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University
Junjie Zhao: Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
Hao Chen: Department of General Surgery, Zhongshan Hospital, General Surgery Research Institute, Fudan University
Lixin Wan: Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
Hiroyuki Inuzuka: Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
Jianping Guo: Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School
Xuhong Fu: Key Laboratory of Systems Biomedicine (Ministry of Education) and Collaborative Innovation Center of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University
Yangyang Zhai: Key Laboratory of Systems Biomedicine (Ministry of Education) and Collaborative Innovation Center of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University
Zhaoning Lu: Key Laboratory of Systems Biomedicine (Ministry of Education) and Collaborative Innovation Center of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University
Xuefei Wang: Department of General Surgery, Zhongshan Hospital, General Surgery Research Institute, Fudan University
Ze-Guang Han: Key Laboratory of Systems Biomedicine (Ministry of Education) and Collaborative Innovation Center of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University
Yihong Sun: Department of General Surgery, Zhongshan Hospital, General Surgery Research Institute, Fudan University
Wenyi Wei: Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School

DOI: https://doi.org/10.1038/s41467-018-06038-y
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

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Upstream pathways regulating Brg1 stability and their role in carcinogenesis are unknown. Here they show Brg1 to be phosphorylated by CK1δ to promote its ubiquitination by SCFFBW7 (FBW7), Brg1 stabilization to promote gastric cancer metastasis, and suggest targeting Brg1 in FBW7 compromised gastric cancer.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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