Nature Communications (Feb 2021)
Genome evolution and the emergence of pathogenicity in avian Escherichia coli
- Leonardos Mageiros,
- Guillaume Méric,
- Sion C. Bayliss,
- Johan Pensar,
- Ben Pascoe,
- Evangelos Mourkas,
- Jessica K. Calland,
- Koji Yahara,
- Susan Murray,
- Thomas S. Wilkinson,
- Lisa K. Williams,
- Matthew D. Hitchings,
- Jonathan Porter,
- Kirsty Kemmett,
- Edward J. Feil,
- Keith A. Jolley,
- Nicola J. Williams,
- Jukka Corander,
- Samuel K. Sheppard
Affiliations
- Leonardos Mageiros
- The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Claverton Down
- Guillaume Méric
- The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Claverton Down
- Sion C. Bayliss
- The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Claverton Down
- Johan Pensar
- Department of Biostatistics, University of Oslo
- Ben Pascoe
- The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Claverton Down
- Evangelos Mourkas
- The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Claverton Down
- Jessica K. Calland
- The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Claverton Down
- Koji Yahara
- Antimicrobial Resistance Research Centre, National Institute of Infectious Diseases
- Susan Murray
- Uppsala University, Department for medical biochemistry and microbiology, Uppsala University
- Thomas S. Wilkinson
- Swansea University Medical School, Institute of Life Science
- Lisa K. Williams
- Swansea University Medical School, Institute of Life Science
- Matthew D. Hitchings
- Swansea University Medical School, Institute of Life Science
- Jonathan Porter
- National Laboratory Service, Environment Agency
- Kirsty Kemmett
- Department of Epidemiology and Population Health, Institute of Infection & Global Health, University of Liverpool, Leahurst Campus
- Edward J. Feil
- The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Claverton Down
- Keith A. Jolley
- Department of Zoology, University of Oxford, South Parks Road
- Nicola J. Williams
- Department of Epidemiology and Population Health, Institute of Infection & Global Health, University of Liverpool, Leahurst Campus
- Jukka Corander
- Department of Biostatistics, University of Oslo
- Samuel K. Sheppard
- The Milner Centre for Evolution, Department of Biology and Biochemistry, University of Bath, Claverton Down
- DOI
- https://doi.org/10.1038/s41467-021-20988-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
It is unclear how gut-dwelling E. coli bacteria often emerge to cause systemic infection in chickens. Here, Mageiros et al. use population genomics and pangenome-wide association studies to identify genetic elements associated with pathogenicity in avian E. coli.
