Association of Sarcopenia with Cognitive Function and Dementia Risk Score: A National Prospective Cohort Study
Ailing Lin,
Ting Wang,
Chenxi Li,
Fan Pu,
Zeinab Abdelrahman,
Mengqi Jin,
Zhenqing Yang,
Liming Zhang,
Xingqi Cao,
Kaili Sun,
Tongyao Hou,
Zuyun Liu,
Liying Chen,
Zuobing Chen
Affiliations
Ailing Lin
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China
Ting Wang
The Second Affiliated Hospital and School of Public Health, The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou 310058, China
Chenxi Li
The Second Affiliated Hospital and School of Public Health, The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou 310058, China
Fan Pu
The Second Affiliated Hospital and School of Public Health, The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou 310058, China
Zeinab Abdelrahman
Department of Neurobiology and Department of Orthopedics, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
Mengqi Jin
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China
Zhenqing Yang
The Second Affiliated Hospital and School of Public Health, The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou 310058, China
Liming Zhang
The Second Affiliated Hospital and School of Public Health, The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou 310058, China
Xingqi Cao
The Second Affiliated Hospital and School of Public Health, The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou 310058, China
Kaili Sun
The Second Affiliated Hospital and School of Public Health, The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou 310058, China
Tongyao Hou
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China
Zuyun Liu
The Second Affiliated Hospital and School of Public Health, The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Zhejiang University School of Medicine, Hangzhou 310058, China
Liying Chen
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China
Zuobing Chen
Department of Rehabilitation Medicine, First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Rd., Hangzhou 310003, China
The relationship between skeletal muscle and cognitive disorders has drawn increasing attention. This study aims to examine the associations of sarcopenia with cognitive function and dementia risk score. Data on 1978 participants (aged 65 years and older) from the 2011 wave of the China Health and Retirement Longitudinal Study, with four follow-up waves to 2018, were used. Cognitive function was assessed by four dimensions, with a lower score indicating lower cognitive function. Dementia risk was assessed by a risk score using the Rotterdam Study Basic Dementia Risk Model (BDRM), with a higher score indicating a greater risk. Sarcopenia was defined when low muscle mass plus low muscle strength or low physical performance were met. We used generalized estimating equations to examine the associations of sarcopenia. In the fully adjusted models, sarcopenia was significantly associated with lower cognitive function (standardized, β = −0.15; 95% CIs: −0.26, −0.04) and a higher BDRM score (standardized, β = 0.42; 95% CIs: 0.29, 0.55). Our findings may provide a new avenue for alleviating the burden of cognitive disorders by preventing sarcopenia.
