Beilstein Journal of Organic Chemistry (Jul 2011)
Multicomponent reaction access to complex quinolines via oxidation of the Povarov adducts
Abstract
The tetrahydroquinolines obtained through the Povarov multicomponent reaction have been oxidized to the corresponding quinoline, giving access to a single product through a two-step sequence. Several oxidizing agents were studied and manganese dioxide proved to be the reagent of choice, affording higher yields, cleaner reactions and practical protocols.
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