Copper depletion modulates mitochondrial oxidative phosphorylation to impair triple negative breast cancer metastasis

Divya Ramchandani; Mirela Berisa; Diamile A. Tavarez; Zhuoning Li; Matthew Miele; Yang Bai; Sharrell B. Lee; Yi Ban; Noah Dephoure; Ronald C. Hendrickson; Suzanne M. Cloonan; Dingcheng Gao; Justin R. Cross; Linda T. Vahdat; Vivek Mittal

doi:10.1038/s41467-021-27559-z

Nature Communications (Dec 2021)

Copper depletion modulates mitochondrial oxidative phosphorylation to impair triple negative breast cancer metastasis

Divya Ramchandani,
Mirela Berisa,
Diamile A. Tavarez,
Zhuoning Li,
Matthew Miele,
Yang Bai,
Sharrell B. Lee,
Yi Ban,
Noah Dephoure,
Ronald C. Hendrickson,
Suzanne M. Cloonan,
Dingcheng Gao,
Justin R. Cross,
Linda T. Vahdat,
Vivek Mittal

Affiliations

Divya Ramchandani: Department of Cardiothoracic Surgery, Weill Cornell Medicine
Mirela Berisa: Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center
Diamile A. Tavarez: Department of Cardiothoracic Surgery, Weill Cornell Medicine
Zhuoning Li: Department of Microchemistry and Proteomics, Memorial Sloan Kettering Cancer Center
Matthew Miele: Department of Microchemistry and Proteomics, Memorial Sloan Kettering Cancer Center
Yang Bai: Department of Cardiothoracic Surgery, Weill Cornell Medicine
Sharrell B. Lee: Department of Cardiothoracic Surgery, Weill Cornell Medicine
Yi Ban: Department of Cardiothoracic Surgery, Weill Cornell Medicine
Noah Dephoure: Department of Biochemistry, Weill Cornell Medicine
Ronald C. Hendrickson: Department of Microchemistry and Proteomics, Memorial Sloan Kettering Cancer Center
Suzanne M. Cloonan: Department of Pulmonary and Critical Care Medicine, Weill Cornell Medicine
Dingcheng Gao: Department of Cardiothoracic Surgery, Weill Cornell Medicine
Justin R. Cross: Donald B. and Catherine C. Marron Cancer Metabolism Center, Memorial Sloan Kettering Cancer Center
Linda T. Vahdat: Department of Medicine, Breast Medicine Service, Memorial Sloan Kettering Cancer Center
Vivek Mittal: Department of Cardiothoracic Surgery, Weill Cornell Medicine

DOI: https://doi.org/10.1038/s41467-021-27559-z
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 16

Abstract

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Copper depletion has been reported to improve survival in patients with triple negative breast cancer (TNBC) but the underlying mechanisms are not completely understood. Here, the authors show that copper chelation reduces mitochondrial oxidative phosphorylation leading to decreased TNBC metastasis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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