Study on detection of insulin autoimmune antibodies: limitation and countermeasures

Abstract

Insulin autoimmune antibodies (IAA) detection are commonly applied to diagnosis of type 1 diabetes mellitus(T1DM), prediction of incidence risk and disease outcomes. It can also be used for the diagnosis of insulin autoimmune syndrome (IAS) and exogenous insulin antibodies syndrome (EIAS). The problem is that IAA has different subtypes which may lead to uncertainties in the prediction and diagnosis of T1DM since the existing clinical detection technology is limited to subdivide them. Meanwhile, the diabetes complicated with IAS or T1DM complicated with EIAS bring more difficulty in detecting IAA subtype as differentiating endogenous etiology(T1DM and IAS) from exogenous etiology (EIAS). In recent years, the studies on IAA affinity, isotype and antigenic epitope may enable laboratory detection to classify IAA groups, which is worth paying attention to.

Keywords

• |type 1 diabetes|insulin antibodies|insulin autoimmunity syndrome|exogenous insulin antibody positive syndrome