Nature Communications (Mar 2021)
Hyocholic acid species as novel biomarkers for metabolic disorders
- Xiaojiao Zheng,
- Tianlu Chen,
- Aihua Zhao,
- Zhangchi Ning,
- Junliang Kuang,
- Shouli Wang,
- Yijun You,
- Yuqian Bao,
- Xiaojing Ma,
- Haoyong Yu,
- Jian Zhou,
- Miao Jiang,
- Mengci Li,
- Jieyi Wang,
- Xiaohui Ma,
- Shuiping Zhou,
- Yitao Li,
- Kun Ge,
- Cynthia Rajani,
- Guoxiang Xie,
- Cheng Hu,
- Yike Guo,
- Aiping Lu,
- Weiping Jia,
- Wei Jia
Affiliations
- Xiaojiao Zheng
- Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus and Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Tianlu Chen
- Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus and Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Aihua Zhao
- Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus and Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Zhangchi Ning
- School of Chinese Medicine, Hong Kong Baptist University
- Junliang Kuang
- Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus and Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Shouli Wang
- Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus and Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Yijun You
- Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus and Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Yuqian Bao
- Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Diabetes Institute
- Xiaojing Ma
- Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Diabetes Institute
- Haoyong Yu
- Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Diabetes Institute
- Jian Zhou
- Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Diabetes Institute
- Miao Jiang
- Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences
- Mengci Li
- Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus and Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Jieyi Wang
- Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus and Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Xiaohui Ma
- Department of Pharmacology and Toxicology, Tasly Pharmaceutical Co. Ltd
- Shuiping Zhou
- Department of Pharmacology and Toxicology, Tasly Pharmaceutical Co. Ltd
- Yitao Li
- School of Chinese Medicine, Hong Kong Baptist University
- Kun Ge
- Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus and Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Cynthia Rajani
- University of Hawaii Cancer Center
- Guoxiang Xie
- University of Hawaii Cancer Center
- Cheng Hu
- Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Diabetes Institute
- Yike Guo
- School of Chinese Medicine, Hong Kong Baptist University
- Aiping Lu
- School of Chinese Medicine, Hong Kong Baptist University
- Weiping Jia
- Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus and Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- Wei Jia
- Center for Translational Medicine and Shanghai Key Laboratory of Diabetes Mellitus and Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital
- DOI
- https://doi.org/10.1038/s41467-021-21744-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
The early identification of metabolic disorders could improve or prevent overt disease. Here the authors show that the circulating concentration of hyocholic acid (HCA) species is decreased in the context of obesity and diabetes and increased after gastric bypass surgery in humans, and further that serum HCA species are predictive of metabolic outcomes in healthy individuals.
