Nature Communications (Apr 2021)

In situ architecture of neuronal α-Synuclein inclusions

  • Victoria A. Trinkaus,
  • Irene Riera-Tur,
  • Antonio Martínez-Sánchez,
  • Felix J. B. Bäuerlein,
  • Qiang Guo,
  • Thomas Arzberger,
  • Wolfgang Baumeister,
  • Irina Dudanova,
  • Mark S. Hipp,
  • F. Ulrich Hartl,
  • Rubén Fernández-Busnadiego

DOI
https://doi.org/10.1038/s41467-021-22108-0
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 10

Abstract

Read online

The molecular architecture of α-Synuclein (α-Syn) inclusions, pathognomonic of various neurodegenerative disorders, remains unclear. Here, authors use cryo-electron tomography to image neuronal α-Syn inclusions in situ and find that inclusions consist of α-Syn fibrils intermixed with cellular organelles without interacting directly.