Nature Communications (May 2017)

Similarity in viral and host promoters couples viral reactivation with host cell migration

  • Kathrin Bohn-Wippert,
  • Erin N. Tevonian,
  • Melina R. Megaridis,
  • Roy D. Dar

DOI
https://doi.org/10.1038/ncomms15006
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 11

Abstract

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The coevolution of viruses and host cells can be mapped with interactomics. Here the authors identify coupling of human and viral promoters, and show that HIV-reactivation from dormancy is coincident with migration of HIV-infected cells owing to coupling of human CXCR4 and HIV LTR promoters.