BMJ Open Ophthalmology (Oct 2023)
Association of macular pigment optical density with retinal layer thicknesses in eyes with and without manifest primary open-angle glaucoma
- ,
- Steven Bailey,
- Zhe Liu,
- Yao Liu,
- Robert B Wallace,
- Elizabeth Johnson,
- JoAnn E Manson,
- Ronald Gangnon,
- J A Mares,
- Barbara E K Klein,
- Charles Kooperberg,
- Julie Mares,
- Barbara V Howard,
- Shari Ludlam,
- Joan McGowan,
- Leslie Ford,
- Nancy Geller,
- Ross Prentice,
- Andrea LaCroix,
- Marcia L Stefanick,
- Cynthia A Thomson,
- Jennifer Robinson,
- Barbara Blodi,
- Lesley F Tinker,
- Ann Lundquist,
- Heather Stockman,
- Amitha Domalpally,
- Thomas Lawler,
- Catherine Thuruthumaly,
- Tyler Etheridge,
- Thasarat S Vajaranant,
- Billy R Hammond,
- Marine Nalbandyan,
- Corinne Engelman,
- Gloria Sarto,
- Erin LeBlanc,
- Karen Gehrs,
- Lesley Tinker,
- D Max Snodderly,
- Randy Hammond,
- Amy Millen,
- Bill Wooten,
- Jennifer Maykoski Portland,
- Chris Smith Madison,
- Kim Wood,
- Jennie Perry Raymond,
- Iowa City,
- Jean Walshire,
- Christine Sinkey,
- Courtney Blomme,
- Kristen Hall,
- Diane Pauk,
- Esther Mezhibovsky,
- Krista Christensen,
- Jacques Rossouw Bethesda,
- Garnet Anderson Seattle,
- Rebecca Jackson Columbus,
- Tucson Phoenix,
- Jean Wactawski Wende,
- Gainesville Jacksonville,
- Lewis Kuller Pittsburgh,
- Sally Shumaker Winston-Salem,
- Robert Brunner Reno,
- Mark Espeland Winston-Salem
Affiliations
- Steven Bailey
- Zhe Liu
- Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA
- Yao Liu
- Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Department of Hematology-Oncology, Chongqing University Cancer Hospital, Shapingba, Chongqing, China
- Robert B Wallace
- Department of Epidemiology, University of Iowa, Iowa City, Iowa, USA
- Elizabeth Johnson
- JoAnn E Manson
- Ronald Gangnon
- J A Mares
- Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA
- Barbara E K Klein
- Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA
- Charles Kooperberg
- Julie Mares
- Barbara V Howard
- Shari Ludlam
- Joan McGowan
- Leslie Ford
- Nancy Geller
- Ross Prentice
- Andrea LaCroix
- 2Group Health Cooperative, Seattle, United States of America
- Marcia L Stefanick
- Cynthia A Thomson
- Jennifer Robinson
- Barbara Blodi
- Lesley F Tinker
- Department of Cancer Prevention, Fred Hutchinson Cancer Center, Seattle, Washington, USA
- Ann Lundquist
- Heather Stockman
- Amitha Domalpally
- Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA
- Thomas Lawler
- Department of Nutritional Sciences, College of Agricultural & Life Sciences, University of Wisconsin, Madison, Wisconsin, USA
- Catherine Thuruthumaly
- Ophthalmology & Visual Sciences, Medical College of Wisconsin, Milwaukee, Wisconsin, USA
- Tyler Etheridge
- Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA
- Thasarat S Vajaranant
- Department of Ophthalmology & Visual Sciences, University of Illinois, Chicago, Illinois, USA
- Billy R Hammond
- Department of Psychology, University of Georgia, Athens, Georgia, USA
- Marine Nalbandyan
- Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, Wisconsin, USA
- Corinne Engelman
- Gloria Sarto
- Erin LeBlanc
- Karen Gehrs
- Lesley Tinker
- D Max Snodderly
- Randy Hammond
- Amy Millen
- Bill Wooten
- Jennifer Maykoski Portland
- Chris Smith Madison
- Kim Wood
- Jennie Perry Raymond
- Iowa City
- Jean Walshire
- Christine Sinkey
- Courtney Blomme
- Kristen Hall
- Diane Pauk
- Esther Mezhibovsky
- Krista Christensen
- Jacques Rossouw Bethesda
- Garnet Anderson Seattle
- Rebecca Jackson Columbus
- Tucson Phoenix
- Jean Wactawski Wende
- Gainesville Jacksonville
- Lewis Kuller Pittsburgh
- Sally Shumaker Winston-Salem
- Robert Brunner Reno
- Mark Espeland Winston-Salem
- DOI
- https://doi.org/10.1136/bmjophth-2023-001331
- Journal volume & issue
-
Vol. 8,
no. 1
Abstract
Objective To investigate associations between baseline macular pigment optical density (MPOD) and retinal layer thicknesses in eyes with and without manifest primary open-angle glaucoma (POAG) in the Carotenoids in Age-Related Eye Disease Study 2 (CAREDS2).Methods and analysis MPOD was measured at CAREDS baseline (2001–2004) via heterochromatic flicker photometry (0.5° from foveal centre). Peripapillary retinal nerve fibre layer (RNFL), macular ganglion cell complex (GCC), ganglion cell layer (GCL), inner plexiform layer (IPL), and RNFL thicknesses were measured at CAREDS2 (2016–2019) via spectral-domain optical coherence tomography. Associations between MPOD and retinal thickness were assessed using multivariable linear regression.Results Among 742 eyes (379 participants), manifest POAG was identified in 50 eyes (32 participants). In eyes without manifest POAG, MPOD was positively associated with macular GCC, GCL and IPL thicknesses in the central subfield (P-trend ≤0.01), but not the inner or outer subfields. Among eyes with manifest POAG, MPOD was positively associated with macular GCC, GCL, IPL and RNFL in the central subfield (P-trend ≤0.03), but not the inner or outer subfields, and was positively associated with peripapillary RNFL thickness in the superior and temporal quadrants (P-trend≤0.006).Conclusion We observed a positive association between MPOD and central subfield GCC thickness 15 years later. MPOD was positively associated with peripapillary RNFL superior and temporal quadrant thicknesses among eyes with manifest POAG. Our results linking low MPOD to retinal layers that are structural indicators of early glaucoma provide further evidence that carotenoids may be protective against manifest POAG.
