PeerJ (Oct 2013)

SUMOylation in Trypanosoma brucei

  • Cornelia Andrea Klein,
  • Dorothea Droll,
  • Christine Clayton

DOI
https://doi.org/10.7717/peerj.180
Journal volume & issue
Vol. 1
p. e180

Abstract

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Small ubiquitin like modifier (SUMO) proteins are involved in many processes in eukaryotes. We here show that Trypanosoma brucei SUMO (Tb927.5.3210) modifies many proteins. The levels of SUMOylation were unaffected by temperature changes but were increased by severe oxidative stress. We obtained evidence that trypanosome homologues of the SUMO conjugating enzyme Ubc9 (Tb927.2.2460) and the SUMO-specific protease SENP (Tb927.9.2220) are involved in SUMOylation and SUMO removal, respectively.

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