Lysosomal alterations and decreased electrophysiological activity in CLN3 disease patient-derived cortical neurons

• Sueanne Chear,
• Sharn Perry,
• Richard Wilson,
• Aidan Bindoff,
• Jana Talbot,
• Tyson L. Ware,
• Alexandra Grubman,
• James C. Vickers,
• Alice Pébay,
• Jonathan B. Ruddle,
• Anna E. King,
• Alex W. Hewitt,
• Anthony L. Cook

Affiliations

Sueanne Chear

Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, TAS 7001, Australia

Sharn Perry

Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, TAS 7001, Australia

Richard Wilson

Central Science Laboratory, University of Tasmania, Hobart, TAS 7001, Australia

Aidan Bindoff

Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, TAS 7001, Australia

Jana Talbot

Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, TAS 7001, Australia

Tyson L. Ware

Department of Paediatrics, Royal Hobart Hospital, Hobart, TAS 7000, Australia

Alexandra Grubman

Department of Anatomy and Developmental Biology, Monash University, Clayton, VIC 3800, Australia

James C. Vickers

Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, TAS 7001, Australia

Alice Pébay

Department of Anatomy and Physiology, University of Melbourne, Parkville, VIC 3010, Australia

Jonathan B. Ruddle

Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, East Melbourne, VIC 3002, Australia

Anna E. King

Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, TAS 7001, Australia

Alex W. Hewitt

Menzies Institute for Medical Research, University of Tasmania, Hobart, TAS 7001, Australia

Anthony L. Cook

Wicking Dementia Research and Education Centre, University of Tasmania, Hobart, TAS 7001, Australia