DNA-dependent protein kinase catalytic subunit (DNA-PKcs) drives chronic kidney disease progression in male mice

Yunwen Yang; Suwen Liu; Peipei Wang; Jing Ouyang; Ning Zhou; Yue Zhang; Songming Huang; Zhanjun Jia; Aihua Zhang

doi:10.1038/s41467-023-37043-5

Nature Communications (Mar 2023)

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) drives chronic kidney disease progression in male mice

Yunwen Yang,
Suwen Liu,
Peipei Wang,
Jing Ouyang,
Ning Zhou,
Yue Zhang,
Songming Huang,
Zhanjun Jia,
Aihua Zhang

Affiliations

Yunwen Yang: Department of Nephrology, Children’s Hospital of Nanjing Medical University
Suwen Liu: Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University
Peipei Wang: Department of Nephrology, Children’s Hospital of Nanjing Medical University
Jing Ouyang: Department of Nephrology, Children’s Hospital of Nanjing Medical University
Ning Zhou: Department of Nephrology, Children’s Hospital of Nanjing Medical University
Yue Zhang: Department of Nephrology, Children’s Hospital of Nanjing Medical University
Songming Huang: Department of Nephrology, Children’s Hospital of Nanjing Medical University
Zhanjun Jia: Department of Nephrology, Children’s Hospital of Nanjing Medical University
Aihua Zhang: Department of Nephrology, Children’s Hospital of Nanjing Medical University

DOI: https://doi.org/10.1038/s41467-023-37043-5
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 17

Abstract

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Kidney injury leads to fibrosis during the progression of chronic kidney disease. Here the authors report that the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) drives chronic kidney disease progression in a study with male mice, potentially via TAF7/RAPTOR/mTORC1 signaling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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