A facile one-pot synthesis of novel 2,5-disubstituted-1,3,4-oxadiazoles under conventional and microwave conditions and evaluation of their in vitro antimicrobial activities

Abstract

A rapid and efficient solvent-free synthesis of 2,5-disubstituted-1,3,4-oxadiazoles (3a–l) from fatty acid hydrazides (1a–f) under microwave irradiation is described. The structural elucidation of these compounds is based on their spectral data (IR, 1H NMR, 13C NMR and MS). All the newly synthesized compounds have been screened for their antibacterial and antifungal activities. The compounds 3f, 3j and 3l were found to be most potent anti-microbial agents.

Keywords

• 2,5-Disubstituted-1,3,4-oxadiazoles
• Conventional and microwave synthesis
• Spectral data
• Antimicrobial activities