Communications Biology (Jan 2021)
Gene regulatory networks controlling differentiation, survival, and diversification of hypothalamic Lhx6-expressing GABAergic neurons
- Dong Won Kim,
- Kai Liu,
- Zoe Qianyi Wang,
- Yi Stephanie Zhang,
- Abhijith Bathini,
- Matthew P. Brown,
- Sonia Hao Lin,
- Parris Whitney Washington,
- Changyu Sun,
- Susan Lindtner,
- Bora Lee,
- Hong Wang,
- Tomomi Shimogori,
- John L. R. Rubenstein,
- Seth Blackshaw
Affiliations
- Dong Won Kim
- Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine
- Kai Liu
- Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine
- Zoe Qianyi Wang
- Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine
- Yi Stephanie Zhang
- Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine
- Abhijith Bathini
- Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine
- Matthew P. Brown
- Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine
- Sonia Hao Lin
- Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine
- Parris Whitney Washington
- Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine
- Changyu Sun
- Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine
- Susan Lindtner
- Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California
- Bora Lee
- Center for Neuroscience, Korea Institute of Science and Technology (KIST)
- Hong Wang
- Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine
- Tomomi Shimogori
- RIKEN Center for Brain Science, Laboratory for Molecular Mechanisms of Brain Development
- John L. R. Rubenstein
- Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, UCSF Weill Institute for Neurosciences, University of California
- Seth Blackshaw
- Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine
- DOI
- https://doi.org/10.1038/s42003-020-01616-7
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 16
Abstract
Dong Won Kim and colleagues investigate the mechanisms by which hypothalamic GABAergic neurons differentiate during development. They report that Lhx6 is crucial for the survival of hypothalamic neurons.
