EJC Skin Cancer (Jan 2023)
German S3 guideline “actinic keratosis and cutaneous squamous cell carcinoma” – Long version of the update 2023
- Ulrike Leiter,
- Markus V. Heppt,
- Theresa Steeb,
- Mareike Alter,
- Teresa Amaral,
- Andrea Bauer,
- Falk G. Bechara,
- Jürgen C. Becker,
- Eckhard W. Breitbart,
- Helmut Breuninger,
- Thomas Diepgen,
- Thomas Dirschka,
- Thomas Eigentler,
- A.K. Stephan El Gammal,
- Moritz Felcht,
- Michael J. Flaig,
- Markus Follmann,
- Klaus Fritz,
- Stephan Grabbe,
- Rüdiger Greinert,
- Ralf Gutzmer,
- Axel Hauschild,
- Uwe Hillen,
- Stephan Ihrler,
- Swen Malte John,
- Lukas Kofler,
- Oliver Koelbl,
- Albrecht Krause-Bergmann,
- Klaus Kraywinkel,
- Steffen Krohn,
- Thomas Langer,
- Carmen Loquai,
- Christoph R. Löser,
- Peter Mohr,
- Dorothée Nashan,
- Monika Nothacker,
- Christina Pfannenberg,
- Carmen Salavastru,
- Lutz Schmitz,
- Eggert Stockfleth,
- Rolf-Markus Szeimies,
- Claas Ulrich,
- Susanne Voelter-Mahlknecht,
- Dirk Vordermark,
- Michael Weichenthal,
- Julia Welzel,
- Kai Wermker,
- Susanne Wiegand,
- Claus Garbe,
- Carola Berking
Affiliations
- Ulrike Leiter
- Center of Dermatooncology, University Department of Dermatooncology, Eberhard-Karls-University Tuebingen, Liebermeisterstr. 25, 72076 Tübingen, Germany
- Markus V. Heppt
- Department of Dermatology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Ulmenweg 18, 91054 Erlangen, Germany; Comprehensive Cancer Center Erlangen-European Metropolitan Area of Nuernberg, (CCC ER-EMN), Erlangen, Germany; Corresponding author at: Department of Dermatology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg, Ulmenweg 18, 91054 Erlangen, Germany.
- Theresa Steeb
- Department of Dermatology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Ulmenweg 18, 91054 Erlangen, Germany; Comprehensive Cancer Center Erlangen-European Metropolitan Area of Nuernberg, (CCC ER-EMN), Erlangen, Germany
- Mareike Alter
- Department of Dermatology, Johannes Wesling Medical Center, Ruhr University Bochum Campus Minden, Hans Nolte Str. 1, 32429 Minden, Germany
- Teresa Amaral
- Center of Dermatooncology, University Department of Dermatooncology, Eberhard-Karls-University Tuebingen, Liebermeisterstr. 25, 72076 Tübingen, Germany
- Andrea Bauer
- Department of Dermatology, University Hospital Carl Gustav Carus, Technical University Dresden, Fetscherstr. 74, 01307 Dresden, Germany
- Falk G. Bechara
- Department of Dermatology, Venerology, and Allergology - St. Josef-Hospital, Ruhr-University Bochum, Gudrunstr. 56, 44791 Bochum, Germany
- Jürgen C. Becker
- Translational Skin Cancer Research (TSCR), DKTK Essen/Düsseldorf, University Medicine Essen, Universitätsstr. 1, 45141 Essen, Germany
- Eckhard W. Breitbart
- Association of Dermatological Prevention, Am Krankenhaus 1a, 21614 Buxtehude, Germany
- Helmut Breuninger
- Comprehensive Cancer Center Erlangen-European Metropolitan Area of Nuernberg, (CCC ER-EMN), Erlangen, Germany
- Thomas Diepgen
- Institute of Clinical Social Medicine, University Heidelberg, Heidelberg, Germany
- Thomas Dirschka
- CentroDerm Wupperthal, Heinz-Fangman-Str. 57, 42287 Wupperthal, Germany
- Thomas Eigentler
- Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt Universität zu Berlin, Charitéplatz 1, 10117 Berlin, Germany
- A.K. Stephan El Gammal
- Clinic of Dermatology, Hospital Bethesda, Euelsbruchstr. 39, 57258 Freudenberg, Germany
- Moritz Felcht
- Department of Dermatosurgery, St. Josefhospital Heidelberg GmbH, Landhausstr. 25, 69115 Heidelberg, Germany; Department of Dermatology, Venereology und Allergy, University Medicine Mannheim, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany
- Michael J. Flaig
- Department of Dermatology and Allergy, University Hospital, LMU Munich, Frauenlobstr. 9-11, 80337 München, Germany
- Markus Follmann
- German Guideline Program in Oncology, German Cancer Society, Kuno-Fischer-Str. 8, 14057 Berlin, Germany
- Klaus Fritz
- Dermatology and Laser Consultation Center, Reduitstr. 13, 76829 Landau, Germany
- Stephan Grabbe
- University of Mainz Medical Center, Department of Dermatology, Langenbeckstr. 1, 55131 Mainz, Germany
- Rüdiger Greinert
- Elbe Clinics Stade Buxtehude GmbH, Medical Center Buxtehude, Am Krankenhaus 1, 21614 Buxtehude, Germany
- Ralf Gutzmer
- Department of Dermatology, Johannes Wesling Medical Center, Ruhr University Bochum Campus Minden, Hans Nolte Str. 1, 32429 Minden, Germany
- Axel Hauschild
- Department of Dermatology, University Hospital Schleswig-Holstein Campus Kiel, Arnold-Heller-Str.3, 24105 Kiel, Germany
- Uwe Hillen
- Department of Dermatology & Venerology, Vivantes Hospital Neukölln, Rudower Str. 48, 12351 Berlin, Germany
- Stephan Ihrler
- DERMPATH Muenchen, Bayerstr. 69, 80335 Muenchen, Germany
- Swen Malte John
- Department of Dermatology and Environmental Medicine, University of Osnabrueck, Institute for Interdisciplinary Dermatological Prevention and Rehabilitation (iDerm) at the University of Osnabrueck, Am Finkenhügel 7a, 49076 Osnabrück, Germany
- Lukas Kofler
- Study Center for Dermatosurgery, University Hospital Tuebingen, Eberhard-Karls-University, Liebermeisterstr. 25, 72076 Tübingen, Germany
- Oliver Koelbl
- Clinic and Polyclinic for Radiooncology, University Medical Center Regensburg, Franz-Josef Strauß Allee 11, 93051 Regensburg, Germany
- Albrecht Krause-Bergmann
- Clinic for Trauma-, Orthopedics-, and Plastic Surgery, Department for Plastic-, Aesthetic, and Handsurgery, Reckenberger Str. 19, 33332 Gütersloh, Germany
- Klaus Kraywinkel
- Robert Koch-Institute, General-Pape-Str. 62–66, 12101 Berlin, Germany
- Steffen Krohn
- German Social Accident Insurance (DGUV), Glinkastr. 40, 10117 Berlin, Germany
- Thomas Langer
- German Guideline Program in Oncology, German Cancer Society, Kuno-Fischer-Str. 8, 14057 Berlin, Germany
- Carmen Loquai
- Department of Dermatology, Medical Center Bremen-Ost, Züricher Str. 40, 28325 Bremen, Germany
- Christoph R. Löser
- Skin Hospital, Skin Cancer Center, Ludwigshafen Hospital, Bremserstr. 79, 67063 Ludwigshafen, Germany
- Peter Mohr
- Elbe Clinics Stade Buxtehude GmbH, Medical Center Buxtehude, Am Krankenhaus 1, 21614 Buxtehude, Germany
- Dorothée Nashan
- Department of Dermatology, Klinikum Dortmund, Beurhausstr. 40, 44137 Dortmund, Germany
- Monika Nothacker
- Association of the Scientific Medical Societies in Germany (AWMF), Institute for Medical Knowledge Management, c/o Philipps Universität Marburg, Karl-von-Frisch-Str. 1, 35043 Marburg, Germany
- Christina Pfannenberg
- Department of Diagnostic and Interventional Radiology, Eberhard-Karls-University Tuebingen, Liebermeisterstr. 25, 72076 Tübingen, Germany
- Carmen Salavastru
- Pediatric Dermatology Discipline, Dermato-oncology Research Facility, ''Colentina'' Clinical Hospital, 19-21 Stefan cel Mare Str., Bucharest 020125, Romania; ''Carol Davila'' University of Medicine and Pharmacy, 37 Dionisie Lupu Str., Bucharest 020021, Romania
- Lutz Schmitz
- CentroDerm Wupperthal, Heinz-Fangman-Str. 57, 42287 Wupperthal, Germany
- Eggert Stockfleth
- Department of Dermatology, Venerology, and Allergology - St. Josef-Hospital, Ruhr-University Bochum, Gudrunstr. 56, 44791 Bochum, Germany
- Rolf-Markus Szeimies
- Department of Dermatology and Allergology, Klinikum Vest GmbH, Dorstener Str. 151, 45657 Recklinghausen, Germany
- Claas Ulrich
- Dermatologie am Regierungsviertel, Luisenstr. 54/55, 10117 Berlin, Germany
- Susanne Voelter-Mahlknecht
- Institute of Occupational Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
- Dirk Vordermark
- Department of Radiation Oncology, Martin-Luther-University Halle-Wittenberg, Ernst-Grube-Str. 40, 06120 Halle/Saale, Germany
- Michael Weichenthal
- Department of Dermatology, University Hospital Schleswig-Holstein Campus Kiel, Arnold-Heller-Str.3, 24105 Kiel, Germany
- Julia Welzel
- Department of Dermatology, University Hospital Augsburg, Sauerbruchstraße 6, 86179 Augsburg, Germany
- Kai Wermker
- Klinikum Osnabrueck, Department for Oral and Maxillofacial Surgery, Plastic and Aesthetic Operations, Am Finkenhügel 1-3, 49076 Osnabrück, Germany
- Susanne Wiegand
- Department of Otorhinolaryngology, Head and Neck Surgery, University Hospital Leipzig, Liebigstr. 12, 04103 Leipzig, Germany
- Claus Garbe
- Center of Dermatooncology, University Department of Dermatooncology, Eberhard-Karls-University Tuebingen, Liebermeisterstr. 25, 72076 Tübingen, Germany
- Carola Berking
- Department of Dermatology, Uniklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU), Ulmenweg 18, 91054 Erlangen, Germany; Comprehensive Cancer Center Erlangen-European Metropolitan Area of Nuernberg, (CCC ER-EMN), Erlangen, Germany
- Journal volume & issue
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Vol. 1
p. 100004
Abstract
Actinic keratosis (AK) are common lesions in light-skinned individuals that can potentially progress to cutaneous squamous cell carcinoma (cSCC). Both conditions may be associated with significant morbidity and constitute a major disease burden, especially among the elderly. To establish an evidence-based framework for clinical decision making, the guideline “actinic keratosis and cutaneous squamous cell carcinoma” was updated and expanded by the topics cutanepus squamous cell carcinoma in situ (Bowen’s disease) and actinic cheilitis. This guideline was developed at the highest evidence level (S3) and is aimed at dermatologists, general practitioners, ear nose and throat specialists, surgeons, oncologists, radiologists and radiation oncologists in hospitals and office-based settings, as well as other medical specialties, policy makers and insurance funds involved in the diagnosis and treatment of patients with AK and cSCC.
