Nature Communications (Apr 2021)
IP6-assisted CSN-COP1 competition regulates a CRL4-ETV5 proteolytic checkpoint to safeguard glucose-induced insulin secretion
- Hong Lin,
- Yuan Yan,
- Yifan Luo,
- Wing Yan So,
- Xiayun Wei,
- Xiaozhe Zhang,
- Xiaoli Yang,
- Jun Zhang,
- Yang Su,
- Xiuyan Yang,
- Bobo Zhang,
- Kangjun Zhang,
- Nan Jiang,
- Billy Kwok Chong Chow,
- Weiping Han,
- Fengchao Wang,
- Feng Rao
Affiliations
- Hong Lin
- School of Life Sciences, Department of Biology, Southern University of Science and Technology, Shenzhen
- Yuan Yan
- School of Life Sciences, Department of Biology, Southern University of Science and Technology, Shenzhen
- Yifan Luo
- School of Life Sciences, Department of Biology, Southern University of Science and Technology, Shenzhen
- Wing Yan So
- Singapore Bioimaging Consortium, Agency for Science, Technology, and Research
- Xiayun Wei
- School of Life Sciences, Department of Biology, Southern University of Science and Technology, Shenzhen
- Xiaozhe Zhang
- School of Life Sciences, Department of Biology, Southern University of Science and Technology, Shenzhen
- Xiaoli Yang
- School of Life Sciences, Department of Biology, Southern University of Science and Technology, Shenzhen
- Jun Zhang
- School of Life Sciences, Department of Biology, Southern University of Science and Technology, Shenzhen
- Yang Su
- School of Life Sciences, Department of Biology, Southern University of Science and Technology, Shenzhen
- Xiuyan Yang
- School of Life Sciences, Department of Biology, Southern University of Science and Technology, Shenzhen
- Bobo Zhang
- School of Life Sciences, Department of Biology, Southern University of Science and Technology, Shenzhen
- Kangjun Zhang
- Department of Hepatic Surgery, the Third People’s Hospital of Shenzhen and the Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen
- Nan Jiang
- Department of Hepatic Surgery, the Third People’s Hospital of Shenzhen and the Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen
- Billy Kwok Chong Chow
- School of Biological Sciences, The University of Hong Kong
- Weiping Han
- Singapore Bioimaging Consortium, Agency for Science, Technology, and Research
- Fengchao Wang
- National Institute of Biological Sciences
- Feng Rao
- School of Life Sciences, Department of Biology, Southern University of Science and Technology, Shenzhen
- DOI
- https://doi.org/10.1038/s41467-021-22941-3
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 13
Abstract
Mediators of insulin signalling are targets of cullin-RING ubiquitin ligases (CRL) that mediate protein degradation, but the role of protein degradation in insulin signalling is incompletely understood. Here, the authors identified a glucose-responsive CRL4-COP1-ETV5 proteolytic axis that promotes insulin secretion, and is inhibited under hypoglycemia.
