Nature Communications (Aug 2019)

The predominance of nucleotidyl activation in bacterial phosphonate biosynthesis

  • Kyle Rice,
  • Kissa Batul,
  • Jacqueline Whiteside,
  • Jayne Kelso,
  • Monica Papinski,
  • Edward Schmidt,
  • Alena Pratasouskaya,
  • Dacheng Wang,
  • Rebecca Sullivan,
  • Christopher Bartlett,
  • Joel T. Weadge,
  • Marc W. Van der Kamp,
  • Gabriel Moreno-Hagelsieb,
  • Michael D. Suits,
  • Geoff P. Horsman

DOI
https://doi.org/10.1038/s41467-019-11627-6
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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Phosphonate modifications can be present on microbial cell surfaces. Here the authors perform bioinformatics analyses and observe a widespread occurrence of nucleotidyltransferase-encoding genes in bacterial phosphonate biosynthesis and functionally characterize two of the identified phosphonate specific cytidylyltransferases (PntCs) and determine the crystal structure of T. denticola PntC.