Nature Communications (Jun 2019)

Insights into real-time chemical processes in a calcium sensor protein-directed dynamic library

  • Andrea Canal-Martín,
  • Javier Sastre,
  • María José Sánchez-Barrena,
  • Angeles Canales,
  • Sara Baldominos,
  • Naiara Pascual,
  • Loreto Martínez-González,
  • Dolores Molero,
  • Mª Encarnación Fernández-Valle,
  • Elena Sáez,
  • Patricia Blanco-Gabella,
  • Elena Gómez-Rubio,
  • Sonsoles Martín-Santamaría,
  • Almudena Sáiz,
  • Alicia Mansilla,
  • F. Javier Cañada,
  • Jesús Jiménez-Barbero,
  • Ana Martínez,
  • Ruth Pérez-Fernández

DOI
https://doi.org/10.1038/s41467-019-10627-w
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 13

Abstract

Read online

Dynamic combinatorial chemistry (DCC) is instrumental in the discovery of ligands for pharmaceutical targets. Here, the authors adapted DCC to work at 4 degrees Celsius and used it to identify a ligand for Neuronal Calcium Sensor-1 that promotes NCS-1/Ric8a protein-protein interaction.