Nature Communications (Jan 2018)
RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73
- Angelos Papaspyropoulos,
- Leanne Bradley,
- Asmita Thapa,
- Chuen Yan Leung,
- Konstantinos Toskas,
- Delia Koennig,
- Dafni-Eleftheria Pefani,
- Cinzia Raso,
- Claudia Grou,
- Garth Hamilton,
- Nikola Vlahov,
- Anna Grawenda,
- Syed Haider,
- Jagat Chauhan,
- Ludovico Buti,
- Alexander Kanapin,
- Xin Lu,
- Francesca Buffa,
- Grigory Dianov,
- Alex von Kriegsheim,
- David Matallanas,
- Anastasia Samsonova,
- Magdalena Zernicka-Goetz,
- Eric O’Neill
Affiliations
- Angelos Papaspyropoulos
- CRUK/MRC Oxford Institute, Department of Oncology, University of Oxford
- Leanne Bradley
- CRUK/MRC Oxford Institute, Department of Oncology, University of Oxford
- Asmita Thapa
- CRUK/MRC Oxford Institute, Department of Oncology, University of Oxford
- Chuen Yan Leung
- The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
- Konstantinos Toskas
- CRUK/MRC Oxford Institute, Department of Oncology, University of Oxford
- Delia Koennig
- CRUK/MRC Oxford Institute, Department of Oncology, University of Oxford
- Dafni-Eleftheria Pefani
- CRUK/MRC Oxford Institute, Department of Oncology, University of Oxford
- Cinzia Raso
- Systems Biology Ireland, University College Dublin
- Claudia Grou
- CRUK/MRC Oxford Institute, Department of Oncology, University of Oxford
- Garth Hamilton
- CRUK/MRC Oxford Institute, Department of Oncology, University of Oxford
- Nikola Vlahov
- CRUK/MRC Oxford Institute, Department of Oncology, University of Oxford
- Anna Grawenda
- CRUK/MRC Oxford Institute, Department of Oncology, University of Oxford
- Syed Haider
- Applied Computational Genomics, Department of Oncology, University of Oxford
- Jagat Chauhan
- Applied Computational Genomics, Department of Oncology, University of Oxford
- Ludovico Buti
- Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford
- Alexander Kanapin
- Bioinformatics Research Core, Department of Oncology, University of Oxford
- Xin Lu
- Ludwig Institute for Cancer Research, Nuffield Department of Clinical Medicine, University of Oxford
- Francesca Buffa
- Applied Computational Genomics, Department of Oncology, University of Oxford
- Grigory Dianov
- CRUK/MRC Oxford Institute, Department of Oncology, University of Oxford
- Alex von Kriegsheim
- Systems Biology Ireland, University College Dublin
- David Matallanas
- Systems Biology Ireland, University College Dublin
- Anastasia Samsonova
- Bioinformatics Research Core, Department of Oncology, University of Oxford
- Magdalena Zernicka-Goetz
- The Wellcome Trust/Cancer Research UK Gurdon Institute, University of Cambridge
- Eric O’Neill
- CRUK/MRC Oxford Institute, Department of Oncology, University of Oxford
- DOI
- https://doi.org/10.1038/s41467-017-02786-5
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 15
Abstract
In development, the switch from pluripotency to differentiation is important but it is often unclear how it is regulated. Here, the authors show that the tumour suppressor RASSF1A mediates this switch by promoting YAP-p73 transcription, which in turn enables differentiation.
