Nature Communications (Feb 2021)
microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity
- Takahiro Horie,
- Tetsushi Nakao,
- Yui Miyasaka,
- Tomohiro Nishino,
- Shigenobu Matsumura,
- Fumiko Nakazeki,
- Yuya Ide,
- Masahiro Kimura,
- Shuhei Tsuji,
- Randolph Ruiz Rodriguez,
- Toshimitsu Watanabe,
- Tomohiro Yamasaki,
- Sijia Xu,
- Chiharu Otani,
- Sawa Miyagawa,
- Kazuki Matsushita,
- Naoya Sowa,
- Aoi Omori,
- Jin Tanaka,
- Chika Nishimura,
- Masataka Nishiga,
- Yasuhide Kuwabara,
- Osamu Baba,
- Shin Watanabe,
- Hitoo Nishi,
- Yasuhiro Nakashima,
- Marina R. Picciotto,
- Haruhisa Inoue,
- Dai Watanabe,
- Kazuhiro Nakamura,
- Tsutomu Sasaki,
- Takeshi Kimura,
- Koh Ono
Affiliations
- Takahiro Horie
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
- Tetsushi Nakao
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
- Yui Miyasaka
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
- Tomohiro Nishino
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
- Shigenobu Matsumura
- Laboratory of Physiological Functions of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
- Fumiko Nakazeki
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
- Yuya Ide
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
- Masahiro Kimura
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
- Shuhei Tsuji
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
- Randolph Ruiz Rodriguez
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
- Toshimitsu Watanabe
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
- Tomohiro Yamasaki
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
- Sijia Xu
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
- Chiharu Otani
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
- Sawa Miyagawa
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
- Kazuki Matsushita
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
- Naoya Sowa
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
- Aoi Omori
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
- Jin Tanaka
- Laboratory of Physiological Functions of Food, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
- Chika Nishimura
- Department of Biological Sciences, Graduate School of Medicine, Kyoto University
- Masataka Nishiga
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
- Yasuhide Kuwabara
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
- Osamu Baba
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
- Shin Watanabe
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
- Hitoo Nishi
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
- Yasuhiro Nakashima
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
- Marina R. Picciotto
- Department of Psychiatry and Interdepartmental Neuroscience Program, Yale University School of Medicine
- Haruhisa Inoue
- Center for iPS Cell Research and Application (CiRA), Kyoto University
- Dai Watanabe
- Department of Biological Sciences, Graduate School of Medicine, Kyoto University
- Kazuhiro Nakamura
- Department of Integrative Physiology, Nagoya University Graduate School of Medicine
- Tsutomu Sasaki
- Laboratory of Nutrition Chemistry, Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University
- Takeshi Kimura
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
- Koh Ono
- Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University
- DOI
- https://doi.org/10.1038/s41467-021-21107-5
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 17
Abstract
Adaptive thermogenesis is regulated by central neuronal circuits. Here, the authors show that microRNA-33 in the brain contributes to the maintenance of brown adipose tissue thermogenesis and whole-body energy balance via enhanced sympathetic nerve tone, and regulating the expression of GABAa receptor subunits.
