The principles of experimental traumatic brain injury modelling

Abstract

The contemporary approaches to traumatic brain injury modeling, the principles of functioning and technical characteristics of appropriate equipment are reviewed. The methods describing traumatic brain injury modeling and assessment of brain structural and functional changes caused by trauma are given. Author suggested the combined use of: 1) histological investigation including quantitative estimation of hippocampal pyramidal neurons; 2) assessment of motor dysfunction; 3) assessment of cognitive dysfunction, as reliable morphological and neurological criteria of experimental brain injury severity and therapy efficacy. The information regarding the traumatic brain injury modeling contained in original scientific reports and reviews of literature are analyzed.