Role of Bioactive Compounds in Obesity: Metabolic Mechanism Focused on Inflammation
Esther Ramírez-Moreno,
José Arias-Rico,
Reyna Cristina Jiménez-Sánchez,
Diego Estrada-Luna,
Angélica Saraí Jiménez-Osorio,
Quinatzin Yadira Zafra-Rojas,
José Alberto Ariza-Ortega,
Olga Rocío Flores-Chávez,
Lizbeth Morales-Castillejos,
Eli Mireya Sandoval-Gallegos
Affiliations
Esther Ramírez-Moreno
Academic Area of Nutrition, Interdisciplinary Research Center, Institute of Health Sciences, Circuit Actopan Tilcuautla s/n, Ex hacienda La Concepción, San Agustin Tlaxiaca, Pachuca 42160, Mexico
José Arias-Rico
Academic Area of Nursing; Institute of Health Sciences, Circuit Actopan Tilcuautla s/n, Ex hacienda La Concepción, San Agustin Tlaxiaca, Pachuca 42160, Mexico
Reyna Cristina Jiménez-Sánchez
Academic Area of Nursing; Institute of Health Sciences, Circuit Actopan Tilcuautla s/n, Ex hacienda La Concepción, San Agustin Tlaxiaca, Pachuca 42160, Mexico
Diego Estrada-Luna
Academic Area of Nursing; Institute of Health Sciences, Circuit Actopan Tilcuautla s/n, Ex hacienda La Concepción, San Agustin Tlaxiaca, Pachuca 42160, Mexico
Angélica Saraí Jiménez-Osorio
Academic Area of Nursing; Institute of Health Sciences, Circuit Actopan Tilcuautla s/n, Ex hacienda La Concepción, San Agustin Tlaxiaca, Pachuca 42160, Mexico
Quinatzin Yadira Zafra-Rojas
Academic Area of Nutrition, Interdisciplinary Research Center, Institute of Health Sciences, Circuit Actopan Tilcuautla s/n, Ex hacienda La Concepción, San Agustin Tlaxiaca, Pachuca 42160, Mexico
José Alberto Ariza-Ortega
Academic Area of Nutrition, Interdisciplinary Research Center, Institute of Health Sciences, Circuit Actopan Tilcuautla s/n, Ex hacienda La Concepción, San Agustin Tlaxiaca, Pachuca 42160, Mexico
Olga Rocío Flores-Chávez
Academic Area of Nursing; Institute of Health Sciences, Circuit Actopan Tilcuautla s/n, Ex hacienda La Concepción, San Agustin Tlaxiaca, Pachuca 42160, Mexico
Lizbeth Morales-Castillejos
Academic Area of Nursing; Institute of Health Sciences, Circuit Actopan Tilcuautla s/n, Ex hacienda La Concepción, San Agustin Tlaxiaca, Pachuca 42160, Mexico
Eli Mireya Sandoval-Gallegos
Academic Area of Nutrition, Interdisciplinary Research Center, Institute of Health Sciences, Circuit Actopan Tilcuautla s/n, Ex hacienda La Concepción, San Agustin Tlaxiaca, Pachuca 42160, Mexico
Obesity is a disease characterized by an inflammatory process in the adipose tissue due to diverse infiltrated immune cells, an increased secretion of proinflammatory molecules, and a decreased secretion of anti-inflammatory molecules. On the other hand, obesity increases the risk of several diseases, such as cardiovascular diseases, diabetes, and cancer. Their treatment is based on nutritional and pharmacological strategies. However, natural products are currently implemented as complementary and alternative medicine (CAM). Polyphenols and fiber are naturally compounds with potential action to reduce inflammation through several pathways and play an important role in the prevention and treatment of obesity, as well as in other non-communicable diseases. Hence, this review focuses on the recent evidence of the molecular mechanisms of polyphenols and dietary fiber, from Scopus, Science Direct, and PubMed, among others, by using key words and based on recent in vitro and in vivo studies.
