Clinical Interventions in Aging (Sep 2023)

Collateral Status Modification of the Association Between Blood Pressure Variation Within 72 Hours After Endovascular Treatment and Clinical Outcome in Acute Ischemic Stroke: A Retrospective Cohort Study

  • Jiang X,
  • Gao L,
  • Wang J,
  • Bao J,
  • Fang J,
  • He L

Journal volume & issue
Vol. Volume 18
pp. 1491 – 1499

Abstract

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Xin Jiang,* Lijie Gao,* Jian Wang, Jiajia Bao, Jinghuan Fang, Li He Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jinghuan Fang; Li He, Department of Neurology, West China Hospital, Sichuan University, No. 37 Guoxue Lane, Chengdu, Sichuan Province, 610041, People’s Republic of China, Email [email protected]; [email protected]: Blood pressure variation and collateral status have been reported to be associated with clinical outcome in patients with acute ischemic stroke who received endovascular treatment; however, the relationship between blood pressure variation within 72 hours after EVT and clinical outcome in different collateral status remains unclear.Methods: Acute ischemic stroke patients due to large vessel occlusion with EVT were retrospectively enrolled. We classified participants into poor collateral (ASITN/SIR grade 0.05). However, the association between the mean and coefficient of variation (CV) values of DBP and 3-month mortality was significantly discrepant under different collateral status (P for interaction < 0.05). In the good collateral subgroup, higher mean DBP was associated with a lower risk of 3-month mortality (OR 0.95, 95% CI 0.91– 1, P = 0.033) compared with the poor subgroup (OR 1.04, 95% CI 0.97– 1.1, P = 0.286). In addition, a higher CV of DBP was associated with a higher risk of 3-month mortality (OR 1.24, 95% CI 1.13– 1.36, P < 0.01) compared with poor status (OR 1.08, 95% CI 0.94– 1.23, P=0.275).Conclusion: For patients who received EVT with good collateral status, increased CV of DBP was significantly associated with higher 3-month mortality, while higher mean DBP within 72 h after EVT was associated with a decrease in 3-month mortality.Keywords: acute ischemic stroke, blood pressure variability, clinical outcome, collateral status, endovascular treatment

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