Juvenile myelomonocytic leukemia: Rare case

Abstract

Juvenile myelomonocytic leukemia (JMML) is a malignant disease characterized by excessive proliferation of monocytic and granulocytic cells resulting in clonal defect of the hematopoietic stem cell, which accounts for about 2% of pediatric leukemia in early childhood. İn nowadays; molecular pathology in 85-90% of cases can be detected. Below we present a 2.5 years old girl who was admitted to our clinic with complaints of rash on the skin and mucositis in the mouth. On the examination of the patient; hepatosplenomegaly with skin petechial rash and laboratory tests; leucocytosis, thrombocytopenia and high levels of HbF were detected. In evaluation of peripheral blood smear and bone marrow aspiration were compatible with JMML. In cytogenetic examinations; PTPN 11 mutation was detected. The natural course of case with JMML is poor.

Keywords

• jmml
• rare
• case