Application of Sensing Devices in the Detection of Oral, Pulmonary, and Gastrointestinal Diseases
Weijie Yu,
Shimeng Mou,
Xiaojing Zhang,
Jiaying Sun,
Yingying Xue,
Hangming Xiong,
K. Jimmy Hsia,
Hao Wan,
Ping Wang
Affiliations
Weijie Yu
Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China
Shimeng Mou
Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China
Xiaojing Zhang
Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China
Jiaying Sun
Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China
Yingying Xue
Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China
Hangming Xiong
Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China
K. Jimmy Hsia
Schools of Chemical & Biomedical Engineering, Nanyang Technological University, Singapore 639798, Singapore
Hao Wan
Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China
Ping Wang
Biosensor National Special Laboratory, Key Laboratory of Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China
Biomedical sensing technology is developing at a tremendous pace and is expected to become an effective clinical tool for the diagnosis and monitoring of human health. The development of sensing devices has successfully transformed the specific sensor prototype designed in the laboratory into a commercially feasible clinical disease detection device. Recently, sensing devices have been accelerated and extended to various fields beyond disease detection, including the measurement of gastrointestinal physiological parameters such as pH, VOC detection, small-molecule gas sensing, and noninvasive screening of oral and lung diseases such as oral cancer, gastric cancer, and other major diseases. In this review, the applications of sensors and electronic nose devices in the diagnosis and monitoring of oral, pulmonary, and gastrointestinal diseases are reviewed, as well as the design and application of sensor materials in disease markers and in situ detection. This article also introduces the practical application of sensing devices in human disease detection, critically analyzes their detection mechanisms and clinical utility, and discusses their future development in medicine. We believe that this review will help readers, especially practitioners in the medical field, provide ideas for the development of sensing devices.
