Journal of Inflammation Research (Dec 2022)

A Systemic Inflammation Response Score for Prognostic Prediction in Hepatocellular Carcinoma Patients After Hepatectomy

  • Zhang D,
  • Huo L,
  • Pan Y,
  • Yang Z,
  • Zeng H,
  • Wang X,
  • Chen J,
  • Wang J,
  • Zhang Y,
  • Zhou Z,
  • Chen M,
  • Hu D

Journal volume & issue
Vol. Volume 15
pp. 6869 – 6881

Abstract

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Deyao Zhang,1,2,* Lanqing Huo,1,3,* Yangxun Pan,1,2,* Zhenyun Yang,1,2,* Huilan Zeng,1,2 Xin Wang,1,2 Jinbin Chen,1,2 Juncheng Wang,1,2 Yaojun Zhang,1,2 Zhongguo Zhou,1,2 Minshan Chen,1,2 Dandan Hu1,2 1Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 2Department of Liver Surgery, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 3Department of Radiation Oncology, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People’s Republic of China*These authors contributed equally to this workCorrespondence: Minshan Chen; Dandan Hu, Sun Yat-sen University Cancer Center, 651 Dongfeng East Road, Guangzhou, 510000, People’s Republic of China, Tel +86 13902241061 ; +86 18676630499, Fax +86 8734-3115 ; +86 8734-3115, Email [email protected]; [email protected]: To investigate the value of preoperative systemic inflammation response (SIRS) score in predicting the prognosis of hepatocellular carcinoma (HCC) after hepatectomy.Patients and Methods: The study analyzed 1001 patients with pathologically proven HCC who received curative resection at Sun Yat-sen University Cancer Center between March 2016 and May 2020. Patients were randomly divided into a training cohort (n = 751) and a validation cohort (n = 250). Clinicopathological characteristics were collected retrospectively. The SIRS score formula was based on the results of a multivariate cox analysis of hematological inflammation indexes in the training cohort. Then, a nomogram consisting of the SIRS score was constructed and the calibration plot, areas under the receiver operating characteristic (AUC) curve, and decision curve analysis (DCA) showed good predictive ability.Results: Univariate and multivariate cox analysis revealed that the SIRS score is an independent prognostic factor for OS in HCC patients. A higher SIRS score was associated with a larger maximum lesion diameter, poor tumor differentiation, a greater possibility of vascular invasion, and a more advanced cancer stage. When the nomogram was used to predict 1-year, 3-year, and 5-year survival rates, the AUC in the training cohort was 0.763, 0.712, and 0.687, respectively; In the validation cohort, it was 0.715, 0.648, and 0.614, respectively. The AUC of this nomogram showed significantly better predictive performance than those of commonly used staging systems.Conclusion: The preoperative SIRS score has good efficacy in predicting the prognosis of HCC patients undergoing hepatectomy, and nomograms based on the SIRS score can potentially guide individualized follow-up and adjuvant therapy.Keywords: liver cancer, systemic inflammation response score, hepatocellular carcinoma, HCC, preoperative, Nomogram, prognosis

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