Nature Communications (Oct 2019)

Modular synthesis of α-fluorinated arylmethanes via desulfonylative cross-coupling

  • Masakazu Nambo,
  • Jacky C.-H. Yim,
  • Luiza B. O. Freitas,
  • Yasuyo Tahara,
  • Zachary T. Ariki,
  • Yuuki Maekawa,
  • Daisuke Yokogawa,
  • Cathleen M. Crudden

DOI
https://doi.org/10.1038/s41467-019-11758-w
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 7

Abstract

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α-Fluoromethyl arenes are common substructures in pharmaceuticals and agrochemicals but synthetic routes are still rare. Here the authors describe Pd-catalyzed Suzuki-Miyaura cross-coupling of α-fluorinated benzylic triflones with arylboronic acids affording structurally diverse α-fluorinated diarylmethanes.