Mitochondria-associated regulation in adipose tissues and potential reagents for obesity intervention

Yali Zheng; Ni Yang; Yueshan Pang; Yanju Gong; Hong Yang; Hong Yang; Weijun Ding; Hongya Yang

doi:10.3389/fendo.2023.1132342

Frontiers in Endocrinology (Jun 2023)

Mitochondria-associated regulation in adipose tissues and potential reagents for obesity intervention

Yali Zheng,
Ni Yang,
Yueshan Pang,
Yanju Gong,
Hong Yang,
Hong Yang,
Weijun Ding,
Hongya Yang

Affiliations

Yali Zheng: Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China
Ni Yang: Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China
Yueshan Pang: Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China
Yanju Gong: Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China
Hong Yang: Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China
Hong Yang: School of Medical and Life Sciences/Reproductive & Women-Children Hospital, Chengdu University of Traditional Chinese Medicine, Chengdu, China
Weijun Ding: Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China
Hongya Yang: Department of Fundamental Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu, China

DOI: https://doi.org/10.3389/fendo.2023.1132342
Journal volume & issue: Vol. 14

Abstract

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IntroductionA systematic review analysis was used to assess the profile of mitochondrial involvement in adipose tissue regulation and potential reagents to intervene in obesity through the mitochondrial pathway.MethodsThree databases, PubMed, Web of Science, and Embase, were searched online for literature associated with mitochondria, obesity, white adipose tissue, and brown adipose tissue published from the time of their creation until June 22, 2022, and each paper was screened.Results568 papers were identified, of which 134 papers met the initial selection criteria, 76 were selected after full-text review, and 6 were identified after additional searches. A full-text review of the included 82 papers was performed.ConclusionMitochondria play a key role in adipose tissue metabolism and energy homeostasis, including as potential therapeutic agents for obesity.

Published in Frontiers in Endocrinology

ISSN: 1664-2392 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://www.frontiersin.org/journals/endocrinology

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