The longevity-promoting factor, TCER-1, widely represses stress resistance and innate immunity

Francis R. G. Amrit; Nikki Naim; Ramesh Ratnappan; Julia Loose; Carter Mason; Laura Steenberge; Brooke T. McClendon; Guoqiang Wang; Monica Driscoll; Judith L. Yanowitz; Arjumand Ghazi

doi:10.1038/s41467-019-10759-z

Nature Communications (Jul 2019)

The longevity-promoting factor, TCER-1, widely represses stress resistance and innate immunity

Francis R. G. Amrit,
Nikki Naim,
Ramesh Ratnappan,
Julia Loose,
Carter Mason,
Laura Steenberge,
Brooke T. McClendon,
Guoqiang Wang,
Monica Driscoll,
Judith L. Yanowitz,
Arjumand Ghazi

Affiliations

Francis R. G. Amrit: Departments of Pediatrics, Developmental Biology and Cell Biology and Physiology, University of Pittsburgh School of Medicine; John G. Rangos Sr. Research Center
Nikki Naim: Departments of Pediatrics, Developmental Biology and Cell Biology and Physiology, University of Pittsburgh School of Medicine; John G. Rangos Sr. Research Center
Ramesh Ratnappan: Departments of Pediatrics, Developmental Biology and Cell Biology and Physiology, University of Pittsburgh School of Medicine; John G. Rangos Sr. Research Center
Julia Loose: Departments of Pediatrics, Developmental Biology and Cell Biology and Physiology, University of Pittsburgh School of Medicine; John G. Rangos Sr. Research Center
Carter Mason: Departments of Pediatrics, Developmental Biology and Cell Biology and Physiology, University of Pittsburgh School of Medicine; John G. Rangos Sr. Research Center
Laura Steenberge: Departments of Pediatrics, Developmental Biology and Cell Biology and Physiology, University of Pittsburgh School of Medicine; John G. Rangos Sr. Research Center
Brooke T. McClendon: Magee-Womens Research Institute, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine
Guoqiang Wang: Department of Molecular Biology and Biochemistry, Rutgers, The State University of New York, Nelson Biological Labs
Monica Driscoll: Department of Molecular Biology and Biochemistry, Rutgers, The State University of New York, Nelson Biological Labs
Judith L. Yanowitz: Magee-Womens Research Institute, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine
Arjumand Ghazi: Departments of Pediatrics, Developmental Biology and Cell Biology and Physiology, University of Pittsburgh School of Medicine; John G. Rangos Sr. Research Center

DOI: https://doi.org/10.1038/s41467-019-10759-z
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 16

Abstract

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Resistance to stress is often associated with increased longevity. Using the model organism C. elegans the authors here show that TCER-1 enhances lifespan while at the same time increasing sensitivity to a number of biotic and abiotic stressors.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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