Nature Communications (Jan 2019)
The antimicrobial potential of Streptomyces from insect microbiomes
- Marc G. Chevrette,
- Caitlin M. Carlson,
- Humberto E. Ortega,
- Chris Thomas,
- Gene E. Ananiev,
- Kenneth J. Barns,
- Adam J. Book,
- Julian Cagnazzo,
- Camila Carlos,
- Will Flanigan,
- Kirk J. Grubbs,
- Heidi A. Horn,
- F. Michael Hoffmann,
- Jonathan L. Klassen,
- Jennifer J. Knack,
- Gina R. Lewin,
- Bradon R. McDonald,
- Laura Muller,
- Weilan G. P. Melo,
- Adrián A. Pinto-Tomás,
- Amber Schmitz,
- Evelyn Wendt-Pienkowski,
- Scott Wildman,
- Miao Zhao,
- Fan Zhang,
- Tim S. Bugni,
- David R. Andes,
- Monica T. Pupo,
- Cameron R. Currie
Affiliations
- Marc G. Chevrette
- Laboratory of Genetics, University of Wisconsin-Madison
- Caitlin M. Carlson
- Department of Bacteriology, University of Wisconsin-Madison
- Humberto E. Ortega
- School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo
- Chris Thomas
- Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison
- Gene E. Ananiev
- McArdle Laboratory for Cancer Research, Wisconsin Institute for Medical Research, University of Wisconsin-Madison
- Kenneth J. Barns
- Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison
- Adam J. Book
- Department of Bacteriology, University of Wisconsin-Madison
- Julian Cagnazzo
- Department of Bacteriology, University of Wisconsin-Madison
- Camila Carlos
- Department of Bacteriology, University of Wisconsin-Madison
- Will Flanigan
- Department of Bacteriology, University of Wisconsin-Madison
- Kirk J. Grubbs
- Department of Bacteriology, University of Wisconsin-Madison
- Heidi A. Horn
- Department of Bacteriology, University of Wisconsin-Madison
- F. Michael Hoffmann
- McArdle Laboratory for Cancer Research, Wisconsin Institute for Medical Research, University of Wisconsin-Madison
- Jonathan L. Klassen
- Department of Molecular and Cell Biology, University of Connecticut
- Jennifer J. Knack
- Department of Biology, Large Lakes Observatory, University of Minnesota-Duluth
- Gina R. Lewin
- School of Biological Sciences, Georgia Institute of Technology
- Bradon R. McDonald
- Department of Bacteriology, University of Wisconsin-Madison
- Laura Muller
- Department of Bacteriology, University of Wisconsin-Madison
- Weilan G. P. Melo
- School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo
- Adrián A. Pinto-Tomás
- Center for Research in Microscopic Structures and Department of Biochemistry, School of Medicine, University of Costa Rica
- Amber Schmitz
- Department of Bacteriology, University of Wisconsin-Madison
- Evelyn Wendt-Pienkowski
- Department of Bacteriology, University of Wisconsin-Madison
- Scott Wildman
- Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison
- Miao Zhao
- Department of Medicine, University of Wisconsin School of Medicine and Public Health
- Fan Zhang
- Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison
- Tim S. Bugni
- Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison
- David R. Andes
- Department of Medicine, University of Wisconsin School of Medicine and Public Health
- Monica T. Pupo
- School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo
- Cameron R. Currie
- Department of Bacteriology, University of Wisconsin-Madison
- DOI
- https://doi.org/10.1038/s41467-019-08438-0
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 11
Abstract
Host microbiomes are feasible sources for drug discovery. Here, using large-scale isolations, bioactivity assays and omics, the authors uncover the antimicrobial potential of insect-associated Streptomyces and identify a compound, cyphomycin, active against multidrug-resistant fungal pathogens.
