Generation of two induced pluripotent stem cell lines from individuals without auditory disorders

Shota Okura; Honoka Ishii; Ayano Suzuki; Chika Saegusa; Ko Fujiki; Kenshi Sugano; Noriomi Suzuki; Tsubasa Saeki; Saeko Matsuzaki; Hiroyuki Ozawa; Masato Fujioka; Makoto Hosoya; Hideyuki Okano

Stem Cell Research (Mar 2023)

Generation of two induced pluripotent stem cell lines from individuals without auditory disorders

Shota Okura,
Honoka Ishii,
Ayano Suzuki,
Chika Saegusa,
Ko Fujiki,
Kenshi Sugano,
Noriomi Suzuki,
Tsubasa Saeki,
Saeko Matsuzaki,
Hiroyuki Ozawa,
Masato Fujioka,
Makoto Hosoya,
Hideyuki Okano

Affiliations

Shota Okura: Keio University School of Medicine, Japan
Honoka Ishii: Keio University School of Medicine, Japan
Ayano Suzuki: Keio University School of Medicine, Japan
Chika Saegusa: Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Japan; Department of Molecular Genetics, Kitasato University School of Medicine, Japan; Molecular Genetics Unit, Kitasato University Graduate School of Medical Science, Japan
Ko Fujiki: Keio University School of Medicine, Japan
Kenshi Sugano: Keio University School of Medicine, Japan
Noriomi Suzuki: Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Japan
Tsubasa Saeki: Department of Physiology, Keio University School of Medicine, Japan
Saeko Matsuzaki: Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Japan
Hiroyuki Ozawa: Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Japan
Masato Fujioka: Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Japan; Department of Molecular Genetics, Kitasato University School of Medicine, Japan; Molecular Genetics Unit, Kitasato University Graduate School of Medical Science, Japan; Clinical and Translational Research Center, Keio University Hospital, Japan; Corresponding authors at: Department of Molecular Genetics, Kitasato University School of Medicine, Japan; Keio University School of Medicine, Japan.
Makoto Hosoya: Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Japan; Corresponding authors at: Department of Molecular Genetics, Kitasato University School of Medicine, Japan; Keio University School of Medicine, Japan.
Hideyuki Okano: Department of Physiology, Keio University School of Medicine, Japan; Corresponding authors at: Department of Molecular Genetics, Kitasato University School of Medicine, Japan; Keio University School of Medicine, Japan.

Journal volume & issue: Vol. 67
p. 103017

Abstract

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We report the establishment of two human induced pluripotent stem cell (iPSC) lines from individuals without auditory disorders. Extensive audiometry tests were performed to confirm normal hearing. The generated iPSC lines expressed pluripotency genes and showed differentiation capability into the three germ layers. The iPSC lines will be used as controls for pathological analysis and drug screening for ear disorders.

Published in Stem Cell Research

ISSN: 1873-5061 (Print); 1876-7753 (Online)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Science: Biology (General)
Website: https://www.journals.elsevier.com/stem-cell-research

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