Communications Biology (Nov 2022)

Discovery of an agonistic Siglec-6 antibody that inhibits and reduces human mast cells

  • Julia Schanin,
  • Wouter Korver,
  • Emily C. Brock,
  • John Leung,
  • Zachary Benet,
  • Thuy Luu,
  • Katherine Chang,
  • Alan Xu,
  • Naomi De Freitas,
  • Kenneth Luehrsen,
  • Michael A. Brehm,
  • Alan Wong,
  • Bradford A. Youngblood

DOI
https://doi.org/10.1038/s42003-022-04207-w
Journal volume & issue
Vol. 5, no. 1
pp. 1 – 13

Abstract

Read online

An agonistic Siglec-6 antibody that binds to a membrane-distal domain of Siglec-6 is identified that induces inhibition and reduction of mast cells and suppresses anaphylaxis in a humanized mouse model.